Class-E amplifiers are a type of switching amplifiers with an efficiency that approaches 100%. The harmonic frequency is very important in the design of Class-E amplifiers. In this study, the second harmonic frequency is considered in the design of a Class-E amplifier. The Class-E amplifier has been fabricated on FR4 and has demonstrated a power-added efficiency (PAE) of 74.5% at 1.01 GHz. This result shows that the termination of the second-harmonic output is essential for switching amplifiers.