Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges

Glycosidase-targeting small molecules for biological and therapeutic applications

“…Due to their significant functions in biological systems, numerous a-glucosidase inhibitors have been developed. [231][232][233][234] Representative inhibitors of this enzyme include acarbose, 235 voglibose, 236 and miglitol 237 (IC 50 = 38, 23 and 3.7 mM, respectively) (Fig. 31).…”

Recent developments on microwave-assisted organic synthesis of nitrogen- and oxygen-containing preferred heterocyclic scaffolds

“…Oxygen-containing molecules such as coumarins are also present in nature and display various biological functions. [45][46][47] Chemical modication of these secondary metabolites is needed to obtain diverse derivatives that can fulll 3D chemical space. Thus, microwave-assisted synthetic modication evolved is a powerful tool which can complete reactions in a shorter time and furnish the desired products in high yields.…”

Synthesis of 3‐hydroxy‐2‐naphthohydrazide‐based hydrazones and their implications in diabetic management via in vitro and in silico approaches

“…[1] The inhibition of α-glucosidase reduces the hyperglycemia substantially by delaying the absorption of carbohydrates, [11] thus used as an effective drug to cure T2DM. [12][13][14][15][16] They also lower the rise in postprandial blood sugar levels roughly about 3 mmol/L by retarding the carbohydrate's absorption. These inhibitors are particularly useful for people who are susceptible to lactic acidosis or hypoglycemia and are not suitable for other type of diabetic medicines such as metformin and sulfonylureas.…”