Syphilis in pregnancy, congenital syphilis, and factors associated with mother-to-child transmission in Itapeva, São Paulo, 2010 to 2014.

Neto, Sérgio Eleutério da Silva; Silva, Stael Silvana Bagno Eleutério da; Sartori, Ana Marli Christovam

doi:10.1590/0037-8682-0377-2017

Cited by 8 publications

(7 citation statements)

References 7 publications

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“…However, it worth noting that many records contained missing race/ethnicity classi cation data in P1, which can be considered as a bias in the interpretation of our results. Indeed, the data presented herein corroborate other studies that identi ed a signi cant correlation between these sociodemographic characteristics and SiP [15,[21][22][23][24][25][26][27]29,30,[32][33][34][35][36][37][38]. We suggest that distinct strategies are required to reach more vulnerable populations and to minimize inequalities that enable greater access to health services.…”

Section: Discussionsupporting

confidence: 88%

Analysis of the Space and Time Distribution of Syphilis in Brazil: Cases of Acquired Syphilis from 2010-2018 and Congenital and Syphilis in Pregnant Women from 2001-2017

Âao¹,

Lm²,

WVd³

et al. 2020

Preprint

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Background. In Brazil, the notification of acquired syphilis (AS), congenital syphilis (CS) and syphilis in pregnant women (SiP) is compulsory. Notification data provided by the Ministry of Health (MoH) in combination with the mapping of vulnerable geographic areas is essential to forecasting possible outbreaks and more effectively combating infection through monitoring. We aim evaluated the space and time distribution of reported cases of CS and SiP in Brazil (2001 to 2017), as well as an estimation of cases of AS (2010 to 2018). Methods. A retrospective ecological study was carried out using secondary surveillance data obtained from the Brazilian National Notifiable Diseases Information System (SINAN) database, considering all reported cases of CS and SiP between 2002 to 2017, as well as MoH epidemiological bulletin data regarding cases of AS between 2010 to 2018. Epidemiological characteristics and time trends were analyzed using joinpoint regression models and spatial distribution (three-year moving averages), considering microregions or states/macroregions as units of analysis. Results. A total of 188,630 (5.4/100,000) CS, 235,895 SiP (6.3/100,000) and 479,731 cases of AS (27.4/100,000) were reported during the periods studied. The epidemiological profile of Brazil indicates most reported CS cases occurred among ‘mixed-race’ newborns who were diagnosed within seven days after birth and whose mothers had received prenatal care. Regarding SiP, most cases were among women who self-reported ‘mixed-race’, were aged 20–39 years, had up to eight years of formal education and were diagnosed with primary or latent syphilis. Overall, rates of AS rose around 400% from 2010 to 2018. Nearly all microregions reported at least one case of CS and SiP. From 2012 to 2016, CS cases increased significantly in almost all Brazilian states, most notably in the South, Southeast, and Central-West macroregions, from 2001–2018 and the relative risk of SiP increased around 4,000%. Conclusions. Considering the epidemiological scenario of the infection in Brazil, it is necessary to enhance preventive, control and eradication measures.

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Section: Discussionsupporting

confidence: 88%

Analysis of the Space and Time Distribution of Syphilis in Brazil: Cases of Acquired Syphilis from 2010-2018 and Congenital and Syphilis in Pregnant Women from 2001-2017

Âao¹,

Lm²,

WVd³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 89%

“…One of the main purposes of prenatal care is to assist women in a quali ed and humanized way beginning in the early stages of pregnancy, adopting early screening procedures coupled with timely interventions [28]. Early diagnosis and treatment of SiP, ideally before the 20 th week of pregnancy, can reduce CS-related cases, such as miscarriages, stillbirths, and infant deaths [29]. It is therefore important that all pregnant women be tested at the rst prenatal visit scheduled in the rst trimester of pregnancy, with repeat testing performed at around 28 weeks and in the beginning of the third trimester in order to promptly implement appropriate therapy if necessary [30].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Space and Time Distribution of Syphilis in Brazil: Cases of Acquired Syphilis From 2010-2018 and Congenital and Syphilis in Pregnant Women From 2001-2017

Silva¹,

Leony²,

Souza

et al. 2020

Preprint

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Background. In Brazil, the notification of acquired syphilis (AS), congenital syphilis (CS) and syphilis in pregnant women (SiP) is compulsory. Notification data provided by the Ministry of Health (MoH) in combination with the mapping of vulnerable geographic areas is essential to forecasting possible outbreaks and more effectively combating infection through monitoring. We aim evaluated the space and time distribution of reported cases of CS and SiP in Brazil (2001 to 2017), as well as an estimation of cases of AS (2010 to 2018). Methods. A retrospective ecological study was carried out using secondary surveillance data obtained from the Brazilian National Notifiable Diseases Information System (SINAN) database, considering all reported cases of CS and SiP between 2002 to 2017, as well as MoH epidemiological bulletin data regarding cases of AS between 2010 to 2018. Epidemiological characteristics and time trends were analyzed using joinpoint regression models and spatial distribution (three-year moving averages), considering microregions or states/macroregions as units of analysis. Results. A total of 188,630 (5.4/100,000) CS, 235,895 SiP (6.3/100,000) and 479,731 cases of AS (27.4/100,000) were reported during the periods studied. The epidemiological profile of Brazil indicates most reported CS cases occurred among ‘mixed-race’ newborns who were diagnosed within seven days after birth and whose mothers had received prenatal care. Regarding SiP, most cases were among women who self-reported ‘mixed-race’, were aged 20-39 years, had up to eight years of formal education and were diagnosed with primary or latent syphilis. Overall, rates of AS rose around 400% from 2010 to 2018. Nearly all microregions reported at least one case of CS and SiP. From 2012 to 2016, CS cases increased significantly in almost all Brazilian states, most notably in the South, Southeast, and Central-West macroregions, from 2001-2018 and the relative risk of SiP increased around 4,000%. Conclusions. Considering the epidemiological scenario of the infection in Brazil, it is necessary to enhance preventive, control and eradication measures.

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“…This was quite similar to a previous study in Thailand, which reported the median (IQR) maternal age of 21 (18–32) years among 69 pregnant women [ 23 ], but was lower than the age of mothers with syphilis from other studies. A study from China reported 155 mothers with syphilis, of whom none were under 20 years old [ 10 ], as well as a report of 149 mothers with syphilis from Brazil, whose median age was 24 years old [ 7 ]. Despite the efforts from national campaigns to eliminate congenital syphilis in Thailand and the high proportion of mothers that attended ANC in our study, mothers of 48.4% of neonates (61/126) had no syphilis treatment or inadequate treatment, which was comparable to 41% among 69 pregnant women reported in other studies [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the United States, the number of reported congenital syphilis cases has increased from 8.4 cases per 100,00 live births in 2012 to 33.1 cases per 100,00 live births in 2018, reaching a 20-year high [ 6 ]. A cross-sectional study from a city in Brazil found that the incidence of congenital syphilis increased from 121 to 223 per 100,000 live births in 2011 and 2014, respectively [ 7 ]. Reports on risk factors associated with congenital syphilis from the United States and other countries included lack of prenatal care, lack of antenatal screening, delayed diagnosis of syphilis in pregnant women, untreated or inadequately treated pregnant women, and low socioeconomic status [ 7 , 8 , 9 , 10 ].…”

mentioning

confidence: 99%

Incidence and associated factors of congenital syphilis at a tertiary care center in Thailand

Kulsirichawaroj

Lumbiganon

2023

Asian Biomedicine

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Background: The incidence of congenital syphilis is increasing worldwide, in parallel with the increase of syphilis in the general population. Objectives: This study aimed to determine the incidence and risk factors for congenital syphilis at a referral tertiary care center in Bangkok, Thailand. Methods: This is a case–control study using the hospital medical records of neonates born at our hospital, whose mothers had confirmed syphilis during pregnancy or at delivery between 2011 and 2018. Maternal and neonatal data were reviewed. Neonates were categorized into congenital syphilis according to CDC surveillance case definition for congenital syphilis 2015 and the American Academy of Pediatrics Congenital Syphilis 2018: confirmed and probable were assigned to the case group, while possible and less likely congenital syphilis were used as the control group. Factors associated with congenital syphilis were analyzed using univariable and multivariable analysis. Results: Among 19,558 live births, there were 126 neonates born to mothers with syphilis. Almost 40% of mothers were teenage mothers and 48.4% had inadequate or no syphilis treatment. Forty neonates met the criteria of congenital syphilis giving the incidence of 204 per 100,000 live births (95% confidence interval [CI]: 146–278). Factors associated with congenital syphilis were inadequate treatment of maternal syphilis and preterm birth (adjusted odd ratio [aOR]: 2.69, 95% CI: 1.02–7.11, P = 0.046 and aOR: 2.91; 95% CI: 1.01–8.39, P = 0.049, respectively). Conclusions: The incidence of congenital syphilis in our institution was high. Factors associated with congenital syphilis were inadequate treatment of maternal syphilis and preterm birth. Improvement of prenatal care should be emphasized.

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Syphilis in pregnancy, congenital syphilis, and factors associated with mother-to-child transmission in Itapeva, São Paulo, 2010 to 2014.

Cited by 8 publications

References 7 publications

Analysis of the Space and Time Distribution of Syphilis in Brazil: Cases of Acquired Syphilis from 2010-2018 and Congenital and Syphilis in Pregnant Women from 2001-2017

Analysis of the Space and Time Distribution of Syphilis in Brazil: Cases of Acquired Syphilis from 2010-2018 and Congenital and Syphilis in Pregnant Women from 2001-2017

Analysis of the Space and Time Distribution of Syphilis in Brazil: Cases of Acquired Syphilis From 2010-2018 and Congenital and Syphilis in Pregnant Women From 2001-2017

Incidence and associated factors of congenital syphilis at a tertiary care center in Thailand

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