Syphilis incidence among men who have sex with men in China: results from a meta-analysis

Chen, Guohong; Ya, Cao; Yao, Yuan; Li, Ming; Tang, Weiming; Li, Jianjun; Babu, Giridhara R; Jia, Yong; Huan, Xiping; Xu, Gen‐Xing; Huang, Yang; Fu, Gengfeng; Li, Lei

doi:10.1177/0956462416638224

Cited by 42 publications

(38 citation statements)

References 30 publications

(65 reference statements)

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“…This is consistent with previous studies that found community engagement in sexual health to be associated with increased HIV testing and syphilis testing [35]. This suggests that influencers could be helpful in promoting dual HIV/syphilis testing, given that these related infections often co-occur among MSM in China [39].…”

supporting

confidence: 81%

Leading by Example: Web-Based Sexual Health Influencers Among Men Who Have Sex With Men Have Higher HIV and Syphilis Testing Rates in China (Preprint)

Wu¹,

Tang²,

Lu³

et al. 2018

Preprint

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supporting

confidence: 81%

Leading by Example: Web-Based Sexual Health Influencers Among Men Who Have Sex With Men Have Higher HIV and Syphilis Testing Rates in China (Preprint)

Wu¹,

Tang²,

Lu³

et al. 2018

Preprint

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“…The World Health Organization (WHO) estimates there are 18 million cases worldwide, with 5.6 million new cases each year (2). Although syphilis rates are highest in low-and middle-income regions (3), higher-income settings, including Canada (4), Europe (5,6), United Kingdom (7,8), China (2,(9)(10)(11), and the United States (12,13) are experiencing increasing syphilis rates. Of utmost concern is the increasing occurrence of congenital syphilis, which causes adverse pregnancy outcomes, including stillbirth, early neonatal death, and preterm birth (14).…”

mentioning

confidence: 99%

Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751

Lithgow

Church

Gomez

et al. 2020

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Treponema pallidum subsp. pallidum is the causative agent of syphilis, a human-specific sexually transmitted infection that causes a multistage disease with diverse clinical manifestations. Treponema pallidum undergoes rapid vascular dissemination to penetrate tissue, placental, and blood-brain barriers and gain access to distant tissue sites. The rapidity and extent of T. pallidum dissemination are well documented, but the molecular mechanisms have yet to be fully elucidated. One protein that has been shown to play a role in treponemal dissemination is Tp0751, a T. pallidum adhesin that interacts with host components found within the vasculature and mediates bacterial adherence to endothelial cells under shear flow conditions. In this study, we further explore the molecular interactions of Tp0751-mediated adhesion to the vascular endothelium. We demonstrate that recombinant Tp0751 adheres to human endothelial cells of macrovascular and microvascular origin, including a cerebral brain microvascular endothelial cell line. Adhesion assays using recombinant Tp0751 N-terminal truncations reveal that endothelial binding is localized to the lipocalin fold-containing domain of the protein. We also confirm this interaction using live T. pallidum and show that spirochete attachment to endothelial monolayers is disrupted by Tp0751-specific antiserum. Further, we identify the 67-kDa laminin receptor (LamR) as an endothelial receptor for Tp0751 using affinity chromatography, coimmunoprecipitation, and plate-based binding methodologies. Notably, LamR has been identified as a receptor for adhesion of other neurotropic invasive bacterial pathogens to brain endothelial cells, including Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae, suggesting the existence of a common mechanism for extravasation of invasive extracellular bacterial pathogens. IMPORTANCE Syphilis is a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum subsp. pallidum. The continued incidence of syphilis demonstrates that screening and treatment strategies are not sufficient to curb this infectious disease, and there is currently no vaccine available. Herein we demonstrate that the T. pallidum adhesin Tp0751 interacts with endothelial cells that line the lumen of human blood vessels through the 67-kDa laminin receptor (LamR). Importantly, LamR is also a receptor for meningitis-causing neuroinvasive bacterial pathogens such as Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae. Our findings enhance understanding of the Tp0751 adhesin and present the intriguing possibility that the molecular events of Tp0751-mediated treponemal dissemination may mimic the endothelial interaction strategies of other invasive pathogens.

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“…5 A recent metaanalysis from China shows increasing incidence of Syphilis in MSM population which in turn may lead to higher rates of spread of other sexually transmitted infections (STIs) including HIV. 6 In our study, 9.9% of the MSM had latent syphilis as indicated by VDRL and or TPHA reactivity. Increased incidence may be due to decreased use of condoms, the introduction of antiretroviral therapy free of cost which has resulted in loss of fear of acquiring and transmitting HIV and resurgence of gonorrhoea and syphilis and asymptomatic nature of the disease.…”

Section: Methodsmentioning

confidence: 99%

A clinicoepidemiological study of sexually transmitted infections among men who have sex with men from a tertiary care centre in South India

et al. 2017

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Background: The prevalence of men who have sex with men (MSM) is showing an increasing trend in general population. MSM being a high risk population are more prone to develop sexually transmitted infections (STIs).Methods: With the help of Sevana, a nongovernmental organization (NGO), we were able to mobilize 81 MSM for detailed evaluation. All MSM, after an informed consent were given a behavioural questionnaire, followed by detailed history taking, clinical examination, pre-test counselling and specimen collection.Results: All of them were clinically asymptomatic. Of the total 81 MSM in our study, 27(33.3%) had STIs as evidenced by laboratory investigations. Out of these, 3 (3.7%) had multiple STIs. The most common STI in our study group was asymptomatic herpes gentalis (12.4%), followed by latent syphilis (9.9%) and non gonococcal urethritis (8.6%). Conclusions: The high incidence of asymptomatic STIs among MSMs in our study points to the need for strengthening targeted intervention including condom usage and a compulsory medical check-up and serological screening at least once in six months for early detection and treatment of STIs. This in turn would help us in preventing the transmission of STIs including HIV.

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Syphilis incidence among men who have sex with men in China: results from a meta-analysis

Cited by 42 publications

References 30 publications

Leading by Example: Web-Based Sexual Health Influencers Among Men Who Have Sex With Men Have Higher HIV and Syphilis Testing Rates in China (Preprint)

Leading by Example: Web-Based Sexual Health Influencers Among Men Who Have Sex With Men Have Higher HIV and Syphilis Testing Rates in China (Preprint)

Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751

A clinicoepidemiological study of sexually transmitted infections among men who have sex with men from a tertiary care centre in South India

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