Syphilis Infection in Women

Holman, Katherine M.; Goepfert, Alice R.

doi:10.1002/9781118314937.ch5

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…In situations of penicillin allergy, consultation and appropriate penicillin desensitization should be performed, followed immediately by appropriate therapy. Despite the widespread misperception that 2 (or more) weeks of penicillin are required for effective early syphilis therapy in pregnant women, the recommended dosing and schedule for syphilis therapy in pregnancy is the same as for non-pregnant patients [18]. Ideally, diagnosis and treatment of syphilis in pregnant women should occur during the first or second trimester; worse pregnancy outcomes were associated with syphilis care initiated in the third trimester [19].…”

Section: Pregnant Womenmentioning

confidence: 99%

Clinical management of early syphilis

Holman¹,

Hook

2013

Expert Review of Anti-infective Therapy

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Early syphilis therapy was a focus of intense research in the early 20th century with many and varied approaches being used. The development of penicillin and its efficacy in the treatment of syphilis transformed syphilis management for many with and at risk for infection. However, problems such as beta-lactam allergies and the desire for easily administered, alternate therapies have led to evaluation of multiple other drugs, with doxycycline currently recommended as the main alternative. Ceftriaxone and azithromycin have been shown to be effective, however, each has its own difficulties. Follow-up relies on serological testing, leading to concerns when these tests do not decline appropriately. Given concerns about the potential for increased risk for treatment failure, patients with HIV and pregnant women are of particular concern.

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Section: Pregnant Womenmentioning

confidence: 99%

Clinical management of early syphilis

Holman¹,

Hook

2013

Expert Review of Anti-infective Therapy

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“…Studies have shown that 16-30% of individuals who have had sexual contact with syphilis infected person in the preceding 30 days become infected, and in some cases, the transmission rates may be much higher. 1,2 Syphilis and Human Immunodeficiency Virus (HIV) have played an important role in public health. These two infections overlap, interact, and share significant characteristics.…”

Section: Introductionmentioning

confidence: 99%

Secondary Syphilis in Human Immunodeficiency Virus (HIV)-Infected Men Who Have Sex with Men (MSM): A Case Report

Fernandes¹,

Ervianti²

2020

BIKK

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Background: Recently, the incidence of syphilis among men who have sex with men (MSM) has increased rapidly, especially among Human Immunodeficiency Virus (HIV)-infected MSM. Coinfection with these two organisms alter the symptoms and signs, progression of the disease, and the risk of progressing to the tertiary stage. Purpose: To report a case of secondary syphilis in HIV-infected MSM. Case: A 24-year-old male complaint of multiple redness macule for 1-month duration on his chest, back, groin, palm, and soles. The rash was neither painful nor pruritic. He also complains of hair loss resulting "moth eaten" alopecia. One month before, he had a painless ulcer on his genital, which resolved without treatment. His HIV infection was diagnosed two years earlier. He had been sexually active with multiple homosexual partners without using a condom since 2010. The Venereal Disease Research Laboratory test (VDRL) titer was 1/32, and Treponema pallidum haemagglutination assay (TPHA) was 1/20480. Initial treatment was a single dose of 2.4 million units of benzathine penicillin. Serologic examination was reevaluated on month 1, 3, 6, and 9 after therapy and declined in the third month. Discussion: For HIV-infected persons, the clinical manifestations of syphilis in most of the cases remain the same. However, the lesions are more aggressive, and coexistence of primary and secondary syphilis is more frequent. Serologic tests are accurate and reliable for the diagnosis and for following a patient’s response to treatment. Penicillin is effective but physical and serological follow up is needed. Conclusion: HIV-infected MSM have higher risk of syphilis. Staging is needed to determine the treatment. Serologic examination should be repeated and long enough to monitor the treatment success.

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Syphilis Infection in Women

Cited by 2 publications

References 8 publications

Clinical management of early syphilis

Clinical management of early syphilis

Secondary Syphilis in Human Immunodeficiency Virus (HIV)-Infected Men Who Have Sex with Men (MSM): A Case Report

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