Syphilitic gumma presenting as myelopathy

Tawfik, Samuel; Khong, Peter; Dower, Ashraf; Huynh, William

doi:10.1016/j.jocn.2019.04.023

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…After the systemic anti-syphilis treatment, the symptoms of syphilitic gumma disappeared in our case. As it is extremely rare in clinical practice, almost all of the previously reported spinal syphilitic gumma cases were suspected as spinal tumors and were subjected to the surgery (4,(7)(8)(9)(10)(11)(12)(13)(14). Instead, most of the cerebral syphilitic gumma in the literature can be significantly reduced or completely absorbed after the anti-syphilis treatment, and surgery would be unnecessary (15).…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of Spinal Syphilitic Gumma: A Case Report

Cui

Hou

2020

Front. Neurol.

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Neurosyphilis, which is caused by Treponema pallidum, is a rare sexually transmitted disease involving the central nervous system (CNS). Among all the sub-categories, spinal syphilitic gumma is extremely rare. In previous literature, limited cases of spinal syphilitic gumma have been reported, most of which underwent surgery treatment. In this study, we reported a 46-year-old man, who presented with 5-day numbness of bilateral lower limbs, lower back pain, and irregular defecation. Magnetic resonance imaging (MRI) revealed a homogeneous peripheral enhancement and intramedullary nodule at the T7 level with extensive thoracic cord edema. Combining with laboratory examination results, the syphilitic gumma was considered. One month after the administration of penicillin G, the symptoms vanished. Six months later, MRI indicated no intramedullary nodule.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of Spinal Syphilitic Gumma: A Case Report

Cui

Hou

2020

Front. Neurol.

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Syphilitic Gummata in the Central Nervous System: A Narrative Review and Case Report about a Noteworthy Clinical Manifestation

et al. 2021

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Infection with Treponema pallidum is on the rise. In this narrative literature review, we show that the incidence of rare manifestations of syphilis, such as intracerebral gummata, is increasing and should be considered in the differential diagnosis of intracerebral lesions. With the exemplary case that we present here, we aim to raise awareness of the resurgence of this disease, which should be considered in the differential diagnosis of intracerebral lesions, especially for patients who have a risk profile for syphilis, and serological testing for T. pallidum prior to surgery should be discussed in order to avoid an unnecessary operation.

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Syphilitic gumma presenting as myelopathy

Cited by 2 publications

References 2 publications

Diagnosis and Treatment of Spinal Syphilitic Gumma: A Case Report

Diagnosis and Treatment of Spinal Syphilitic Gumma: A Case Report

Syphilitic Gummata in the Central Nervous System: A Narrative Review and Case Report about a Noteworthy Clinical Manifestation

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