Syphilitic hepatitis: Look for raised alkaline phosphatase level

Aggarwal, Shyam; Radhakrishnan, S.

doi:10.1016/j.mjafi.2015.11.011

Cited by 8 publications

(9 citation statements)

References 8 publications

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“…Finally, a total of 73 articles containing 144 cases of SH in adults with medical records were discovered 2 , 3 , 5 , 6 , 10 – 78 ( Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

“… 4 Liver disease due to syphilis infection has rarely been reported and little is known about syphilitic hepatitis (SH). Maryam et al 5 reported a case of a male with SH who showed multiple liver lesions, while the case published by Aggarwal et al 6 presented with raised alkaline phosphatase levels. Syphilis, especially in its early stages, is often asymptomatic and easily misdiagnosed.…”

Section: Introductionmentioning

confidence: 99%

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A Systematic Literature Review of Syphilitic Hepatitis in Adults

Huang¹,

Lin²,

Wan³

et al. 2018

Journal of Clinical and Translational Hepatology

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Syphilitic hepatitis in adults is not frequently found in the population and is easily misdiagnosed. The incidence of viral hepatitis is increasing year by year, concomitantly increasing the importance of obtaining a systematic understanding of the clinical features and treatment strategies for this disease. There is, however, a lack of published definitive data regarding the clinical characteristics, diagnosis and standard treatment options for this disease. Searches were made using the MEDLINE database of PubMed and OVID for syphilitic hepatitis publications from 1951 to 2017 in an attempt to analyze and summarize the clinical characteristics.

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“…Finally, a total of 73 articles containing 144 cases of SH in adults with medical records were discovered 2 , 3 , 5 , 6 , 10 – 78 ( Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Systematic Literature Review of Syphilitic Hepatitis in Adults

Huang¹,

Lin²,

Wan³

et al. 2018

Journal of Clinical and Translational Hepatology

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“…Disproportionally high serum alkaline phosphatase and GGT levels with slight raised or normal serum transaminases and bilirubin are common. [7][8][9][10][11][12] Serologic testing for the diagnosis of syphilis should include the use of both nontreponemal and treponemal tests. Either test can be used as the initial screening test.…”

Section: Discussionmentioning

confidence: 99%

Syphilitic hepatitis: Case report of an overlooked condition

Marcos

Eliseu

Henrique

et al. 2019

Clinical Case Reports

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractSyphilis is an overlooked cause of hepatitis. Syphilitic hepatitis should be a differential diagnosis in all patients with abnormal liver biochemical marker levels. Syphilitic hepatitis has been defined as the combination of increased liver enzymes, positive serology for syphilis, the absence of alternative causes for hepatobiliary injury, and liver enzyme improvement with proper antibiotic therapy. K E Y W O R D S Syphilis, Syphilitic hepatitis, Treponema pallidumHow to cite this article: Marcos P, Eliseu L, Henrique M, Vasconcelos H. Syphilitic hepatitis: Case report of an overlooked condition. Clin Case Rep.

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“…La sífilis es capaz de comprometer prácticamente cualquier órgano del cuerpo humano, siendo la hepatitis sifilítica una manifestación poco frecuente, descrita entre 0,7 y 2,7% en distintas series 5,9 . El compromiso hepático se puede presentar en sífilis primaria, secundaria o terciaria, siendo la diseminación hematógena la principal hipótesis, ya que sugiere la migración del treponema a través del sistema venoso hasta la circulación hepática, esto planteado al demostrar la presencia del agente en las biopsias hepáticas y su desaparición posterior al tratamiento [10][11][12] .…”

Section: Discussionunclassified

Hepatitis sifilítica: reporte de una serie de casos

et al. 2019

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Syphilitic hepatitis. Report of three cases Liver involvement occurs in 0.2 to 3% of patients with syphilis. We report three patients with liver involvement in syphilis. A 52-year-old male presenting with erythema and malaise. Laboratory showed a gamma glutamyl transpeptidase (GGT) of 853 u/l, alkaline phosphatases of 1,010 U/L and VDRL was positive. Treatment with penicillin resolved the skin problem and normalized liver enzymes. A HIV positive 30-year-old male in peritoneal dialysis presenting with itching, malaise and markedly elevated GGT and alkaline phosphatases. VDRL was positive. He was treated with penicillin with remission of symptoms and enzyme normalization. A 43-year-old male presenting with erythema, malaise, arthralgias and elevated GGT and alkaline phosphatases. VDRL was positive and treatment with penicillin reverted symptoms and laboratory abnormalities.

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Syphilitic hepatitis: Look for raised alkaline phosphatase level

Cited by 8 publications

References 8 publications

A Systematic Literature Review of Syphilitic Hepatitis in Adults

A Systematic Literature Review of Syphilitic Hepatitis in Adults

Syphilitic hepatitis: Case report of an overlooked condition

Hepatitis sifilítica: reporte de una serie de casos

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