Syphilitic meningitis in HIV-patients with meningeal syndrome: report of two cases and review

Carmo, Ricardo Andrade; Moura, Alexandre Sampaio; Christo, Paulo Pereira; Morandi, Ana Cláudia; Oliveira, Marcelo Silva de

doi:10.1590/s1413-86702001000500007

Cited by 12 publications

(6 citation statements)

References 28 publications

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“…NCL interacts with protein p42IP4/centaurin-alpha 1 in the brains of Alzheimer’s patients that often exhibit depression comorbidity (Reiser and Bernstein, 2004). Likewise, ACTN1 is differentially expressed in the frontal cortex of patients diagnosed with HIV and meningitis (Selvan et al, 2015) and these conditions exhibit depression comorbidity (Carmo et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

Rodriguez-Zas

Southey

et al. 2018

Psychoneuroendocrinology

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Section: Discussionmentioning

confidence: 99%

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

Rodriguez-Zas

Southey

et al. 2018

Psychoneuroendocrinology

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“…However, a variety of presentations can occur. An increased frequency of ophthalmologic alterations as well as accelerated late manifestations of neurosyphilis have been described 4,15 . Two patients with confirmed neurosyphilis presented headache without an associated meningeal syndrome.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and evolution of syphilis in 24 HIV+ individuals in Rio de Janeiro, Brazil

Gutierrez-Galhardo

Valle

Sá

et al. 2005

Rev. Inst. Med. trop. S. Paulo

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A total of 24 patients with syphilis and HIV infection were treated from January 1997 to March 2003 at the Infectious Dermatology Outpatient Clinic of the Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. The caseload consisted of 20 males (83.3%) and four females (16.7%), with a mean age of 38.04 years and mean T CD4+ count of 389.5 cells/mL. Syphilis was diagnosed as secondary in 16 (62.5%) patients, late latent in eight (33.3%), and tertiary in one (4.2%). Manifestations of secondary syphilis were palmar and plantar erythematopapulous cutaneous lesions in nine (37.5%), papulous exanthema in four (16.7%), patchy alopecia in 3 (12.5%) and osteochondritis in one patient (4.2%). Tertiary syphilis was characterized by verrucous lesions. Neurosyphilis was diagnosed in four patients (16.7%), with headache as the only manifestation in two patients. Drugs used in treatment included benzathine penicillin, ceftriaxone, erythromycin, and crystalline penicillin. Cure was achieved in 18 patients (75%). Five patients (20.8%) were retreated, three of whom presented a history of re-exposure. This study confirms the importance of establishing the diagnosis of neurosyphilis in patients with HIV infection, in addition to performing follow-up on treatment for syphilis.

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“…Syphilis is a serious infectious disease, which can damage multiple organ systems and present with various clinical presentations [109][110][111]. In 4-9% of patients infected with syphilis (Traponema pallidum) and left untreated, neurosyphilis (NS) might develop as the consequence of involvement of the central nervous system [112,113]. The disease can either be asymptomatic or might present with multiple neurological and psychiatric symptoms such as seizures, ocular disorders, psychiatric/behavioral changes, and less likely tabes dorsalis or general paresis [114].…”

Section: Researchmentioning

confidence: 99%

“…Instead, it is typically based on a combination of clinical evaluation and analysis of CSF findings. CSF VDRL, CSF treponemal tests, CSF pleocytosis, and CSF protein levels should be evaluated [113].…”

Section: Researchmentioning

confidence: 99%

One Patient, Three Providers: A Multidisciplinary Approach to Managing Common Neuropsychiatric Cases

Özge,

Domaç,

Tekin

et al. 2023

JCM

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Background: Neuropsychiatric cases require a multidisciplinary approach for effective management. This paper presented case-based discussions on migraine, dementia, epilepsy, mood disorders, neuralgia, and psychosis from the perspectives of a family physician, neurologist, and psychiatrist. The goal was to highlight the importance of collaboration between healthcare providers in managing these complex cases. Methods: The paper was based on the proceedings of the Mediterranean Neuropsychiatry Symposium, where experts from family medicine, neurology, and psychiatry came together for comprehensive case-based discussions. The CARE framework (Case Report, Appraisal, Research, and Education) was developed to guide reporting and evaluation of case reports in clinical practice. Results: Six cases were presented and discussed, highlighting the importance of a multidisciplinary approach in managing neuropsychiatric cases. The cases included chronic migraine with medication overuse, memory dysfunction with language and behavioral problems, refractory epileptic seizures with subjective sensory symptoms, bipolar affective disorder with normal pressure hydrocephalus, postherpetic neuralgia in a case with bipolar affective disorder, and psychosis with recurrent attacks with the abuse of several substances. Conclusion: A biopsychosocial multidisciplinary approach is essential for managing neuropsychiatric cases effectively on behalf of the patients and public health of the country. The CARE framework can guide the reporting and evaluation of case reports in clinical practice, ensuring that patients receive comprehensive and effective care. Healthcare providers should collaborate to provide the best possible care for patients with complex and multifaceted needs.

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Syphilitic meningitis in HIV-patients with meningeal syndrome: report of two cases and review

Cited by 12 publications

References 28 publications

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

Clinical characteristics and evolution of syphilis in 24 HIV+ individuals in Rio de Janeiro, Brazil

One Patient, Three Providers: A Multidisciplinary Approach to Managing Common Neuropsychiatric Cases

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