Syphilitic Uveitis

Cunningham, Emmett T.; Eandi, Chiara M.; Pichi, Francesco

doi:10.3109/09273948.2014.883236

Cited by 28 publications

(27 citation statements)

References 15 publications

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“…Based on studies with a small number of patients some authors 16 have suggested that HIV positivity may predict a worse outcome. However, in a recent editorial, Cunningham et al 23 support the notion that HIV infection per se does not portend a poor outcome, taking into account two comprehensive retrospective reviews.…”

Section: Resultsmentioning

confidence: 90%

Clinical Manifestations and Outcomes of Syphilis-associated Uveitis in Northern Spain

Fonollosa

Martínez-Indart

Artaraz

et al. 2014

Ocular Immunology and Inflammation

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Section: Resultsmentioning

confidence: 90%

Clinical Manifestations and Outcomes of Syphilis-associated Uveitis in Northern Spain

Fonollosa

Martínez-Indart

Artaraz

et al. 2014

Ocular Immunology and Inflammation

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“…Human immunodeficiency virus (HIV) co-infection in our cohort was related to ocular syphilis but not to the presence of optic nerve involvement. Previous literature indicated that the relationship between HIV infection and increasing severity of ocular syphilis continued to be an unresolved issue (Cunningham et al 2014). While some reports suggested that HIV-positive patients tend to present with predominantly posterior segment involvement and worse visual outcome (Amaratunge et al 2010), others found no difference in visual prognosis (Tran et al 2005;Hughes et al 2010;Tucker et al 2011;Eandi et al 2012;Fonollosa et al 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Previous literature indicated that the relationship between HIV infection and increasing severity of ocular syphilis continued to be an unresolved issue (Cunningham et al. ). While some reports suggested that HIV‐positive patients tend to present with predominantly posterior segment involvement and worse visual outcome (Amaratunge et al.…”

Section: Discussionmentioning

confidence: 99%

The great imitator on the rise: ocular and optic nerve manifestations in patients with newly diagnosed syphilis

Klein

Fischer

Goldstein

et al. 2018

Acta Ophthalmologica

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Purpose Ocular manifestations of syphilis have been reported in 2–10% of systemic infection. The purpose of this study was to report the incidence of ocular syphilis and various ocular manifestations, particularly optic nerve involvement, in newly diagnosed cases. Methods This was a retrospective study. Medical records of newly diagnosed syphilis patients between January 2009 and January 2017 in a tertiary medical centre were reviewed. Results There were 123 new systemic syphilis cases out of 569,222 (0.02%) admissions to the Tel Aviv Medical Center during the study period. Ninety‐three of the 123 patients (76%) underwent ophthalmological examination. Twenty‐three of the 93 patients (25%, mean age 48.6 ± 12.9 years, 20 males) had ocular syphilis, and in 12/23 (52%) patients, the ocular symptoms and findings prompted syphilis investigation. Eighteen of the 23 (78%) had optic nerve involvement, and the most common was inflammatory disc oedema. Older age (p = 0.0005) and tertiary stage disease (p = 0.0441) were associated with ocular manifestations and the presence of optic nerve findings. Human immunodeficiency virus (HIV) was associated with ocular but not optic nerve findings. Treatment included intravenous penicillin G, and four patients with severe optic neuropathy were also treated with systemic corticosteroids. Visual acuity significantly improved in most patients (p < 0.05). Conclusion Ocular syphilis was found in one‐quarter of the patients diagnosed with systemic syphilis and preceded the diagnosis of systemic disease in one‐half of them. Optic nerve involvement was a common manifestation. A high index of suspicion for Treponema infection is required in patients presenting with optic nerve involvement to facilitate prompt diagnosis and treatment. Post‐treatment visual outcome was good.

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“…The relationship between HIV infection and increasing severity of ocular syphilis remains an unresolved issue 23. In the review by Tucker et al ,22 visual prognosis following syphilis treatment was good despite HIV coinfection.…”

Section: Discussionmentioning

confidence: 99%