Syphilitic Uveitis and Dermatitis

Cubillan, Leo Dp; Cubillan, Eileen A.; Berger, Timothy G.; Seiff, Stuart R.; Crawford, J. Brooks; Howes, Edward L.; Cunningham, Emmett T.

doi:10.1001/archopht.116.5.696

Cited by 11 publications

(5 citation statements)

References 4 publications

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“…One hundred and forty‐three original descriptions of patients with syphilitic uveitis were identified. These cases were identified in 41 different papers 2,6,7,9–11,14,17–52 …”

Section: Resultsmentioning

confidence: 99%

Syphilitic uveitis: a review of clinical manifestations and treatment outcomes of syphilitic uveitis in human immunodeficiency virus‐positive and negative patients

Amaratunge

Camuglia

Hall

2010

Clinical Exper Ophthalmology

136

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The incidence of syphilis and syphilitic uveitis in our community is increasing. The prevalence of associated neurosyphilis is unknown, and it remains unclear whether syphilitic uveitis should be treated as secondary syphilis with intramuscular penicillin or neurosyphilis with intravenous penicillin. The (English language) literature was reviewed for all unique cases of syphilitic uveitis reported from 1984 to June 2008. For each case the following data were recorded: the clinical features of the syphilis, the uveitis and any associated neurosyphilis, the human immunodeficiency virus (HIV) status, lumbar puncture findings, treatment and follow up. We identified 143 patients in 41 original reports of syphilitic uveitis (93 HIV-positive and 50 HIV-negative). Posterior uveitis was reported in 79 patients (55.2%); panuveitis was reported in 36 patients (25.2%); anterior/intermediate uveitis was reported in only 28 patients (19.6%). Lumbar puncture findings were abnormal in 82 patients (57%), and the majority of these patients (76%, 62 out of 82) were HIV-positive. One hundred and ten (77%) patients were treated with intravenous therapy, usually penicillin. Most recovered from the syphilis, however, a proportion did not recover full vision. There were 13 (9%) treatment failures, which tended to occur in patients who were HIV-positive (n = 11), had abnormal lumbar puncture findings (n = 8) and/or were treated (n = 11) intravenously. There is a high incidence of abnormal lumbar puncture findings in patients with syphilitic uveitis and a strong association with HIV infection. Most received appropriate therapy with a low relapse rate, which was not related to the type of therapy.

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“…One hundred and forty‐three original descriptions of patients with syphilitic uveitis were identified. These cases were identified in 41 different papers 2,6,7,9–11,14,17–52 …”

Section: Resultsmentioning

confidence: 99%

Syphilitic uveitis: a review of clinical manifestations and treatment outcomes of syphilitic uveitis in human immunodeficiency virus‐positive and negative patients

Amaratunge

Camuglia

Hall

2010

Clinical Exper Ophthalmology

136

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“…Anterior uveitis was found in one case (8.3%). Eleven patients (91.7%) presented with posterior uveitis or panuveitis associated with necrotizing retinitis (seven eyes, Panuveitis associated with necrotizing retinitis was found in four patients (1,5,8,10) leading to a diagnosis of acute retinal necrosis in three patients (3,8,10). These patients were initially treated with intravenous acyclovir or foscarnet.…”

Section: Resultsmentioning

confidence: 99%

“…Ocular syphilis was diagnosed after a negative result from a herpesvirus polymerase chain reaction-based assay from aqueous humor and positive specific treponemal serum antibody tests. Cubillan et al [10] has previously reported a case of syphilitic uveitis which was initially misdiagnosed as an acute retinal necrosis. The term "syphilitic posterior placoid chorioretinitis" was first described by Gass in 1990 [12] in six patients who presented with secondary syphilis.…”

Section: Discussionmentioning

confidence: 99%

Syphilitic uveitis in patients infected with human immunodeficiency virus

Tran

Cassoux

Bodaghi

et al. 2005

Graefe's Arch Clin Exp Ophthalmol

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“…In addition, similar necrotising retinitis may also occur from non-viral infectious agents including Toxoplasma gondii, bacteria, or fungi. [6][7][8][9][10] Other disease entities (namely, retinal vasculitis, intraocular tumours, and sarcoidosis) can also present with retinitis that mimics ARN. [11][12][13][14][15][16][17][18][19][20] Thus, specific and sensitive laboratory tests are necessary to confirm a diagnosis of ARN or the non-viral retinopathies that present with features simulating ARN.…”

mentioning

confidence: 99%