Syringocystadenocarcinoma papilliferum with orbital invasion: a case report with literature review

Abstract

We present a case of Syringocystadenocarcinoma papilliferum that originated in the eyelid and extended into the orbit. These tumors are very rare and have the potential to metastasize. A literature review of all the previous cases has been compiled from the Medline, EMBASE, and PubMed databases. We found that the majority of cases present on the head and neck and up to 17% of cases showed metastatic progression. This is the first case to show orbital involvement and highlights the need to remain vigilant with such lesions, as they have a tendency to become aggressive.

A rare case of syringocystadenocarcinoma papilliferum of the breast: An institutional retrospective case review and brief literature review

“…SCACP is a rare entity described predominantly in case reports and small series. [1][2][3][4][5][6][7][8][9][10] To the best of our knowledge, mammary SCACP has not been previously described, and this constitutes the first case of such an unusual presentation.…”

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation

“…Syringocystadenocarcinoma papilliferum (SCACP) is the malignant counterpart of syringocystadenoma papilliferum (SCAP). Usually, it develops on the scalp in a long-standing lesion identified clinically as SCAP, although due to the rarity of this tumor, etiology and origin are not clarified [ 163 , 164 ]. Lesions are found in the same locations as SCAP.…”

“…In the deeper parts of the tumor, numerous irregular neoplastic tubular and cystic structures, lined by monolayered or multilayered atypical cells with enlarged and hyperchromatic nuclei, diffusely infiltrate the whole dermis in an invasive growth pattern. Occasionally, numerous normal apocrine glands can be found [ 163 ]. The proliferative index is high.…”

Genital syringocystadenocarcinoma papilliferum: An unusual location and review of the literature

“…Syringocystadenocarcinoma papilliferum (SCACP) is a rare malignant adnexal tumor that represents the malignant counterpart of syringocystadenoma papilliferum (SCAP). 1 Mostly, it is believed to arise from SCAP, nevus sebaceous, or linear nevus verrucosus lesions. 2 The majority of cases present on the head and neck and up to 17% of cases show metastatic progression.…”

“… 2 The majority of cases present on the head and neck and up to 17% of cases show metastatic progression. 1 Only 52 cases of this malignancy have been reported to date, with limited data being available about its origin and etiology. Moreover, these tumors seldom occur in the anogenital area; to date, only one case has been reported to appear on the penis.…”