Syringocystadenoma papilliferum in the right lower abdomen: a case report and review of literature

Abstract

Syringocystadenoma papilliferum (SCAP) is an uncommon benign adnexal tumor of the skin. It is frequently seen in association with other benign adnexal lesions, such as nevus sebaceous, apocrine nevus, tubular apocrine adenoma, apocrine hidrocystoma, apocrine cystadenoma, and clear cell syringoma. The unusual reported locations of SCAP include the head and neck, the buttock, the vulva, the scrotum, the pinna, the eyelid, the outer ear canal, the forehead, the back, the scalp, the thigh, the nipple, the axilla, and the postoperative scar. The occurrence of SCAP in the right lower abdomen is distinctly uncommon. Herein, we report an unusual case of a 41-year-old man with SCAP occurring in the right lower abdomen that did not develop malignancy, despite a long disease course and an absence of medical treatment. The clinical and histopathologic features and the differential diagnosis of SCAP are also discussed.

Neonatal syringocystadenoma papilliferum: A case report

“…Most SCAP occur in the head and neck region, and unusual locations comprise the buttock, vulva and scrotum, pinna, eyelid, outer ear canal, postoperative scar, scalp, nipple, thigh, axilla, and back[ 3 ]. Several reports have described cases with SCAP originating from the nevus sebaceous in older women[ 5 - 7 ].…”

“…There are three known clinical forms of SCAP, including plaque, solitary nodular, and linear, and the majority of lesions are found in the head and neck region. SCAP is associated with other noncancerous adnexal tumors, including nevus sebaceous, apocrine nevus, tubular apocrine adenoma, apocrine hidrocystoma, apocrine cystadenoma, and clear cell syringoma[ 3 ]. We here report a 35-day-old girl admitted to Kunming Children’s Hospital in October 2019 due to a lesion in the right frontotemporal region from birth, who was diagnosed with SCAP based on clinical and histopathological features.…”

Syringocystadenoma papilliferum in the scalp, with a linear presentation

“…It can appear as a plaque-type, as a solitary papule, or as several papules with a linear arrangement as in our case. 4 , 5 , 6 …”

“…It usually manifests as a solitary lesion. 4 It is observed at birth in 50% of cases and in 15%‒30% of them it develops during puberty. 6 , 3 The most reported localization is the head and neck area, up to 75% of the cases and, 40% of them develop in association with a pre-existing nevus sebaceous.…”

“…The lesions are usually skin colored to pink, hairless, firm plaques, and solitary or grouped nodules. 4 These may present with smooth flat or dome-shaped surfaces. The larger lesions may ulcerate.…”