Syringol, a wildfire residual methoxyphenol causes cytotoxicity and teratogenicity in zebrafish model

Priya, P. Snega; Guru, Ajay; Meenatchi, R.; Haridevamuthu, B.; Velayutham, Manikandan; Boopathi, Seenivasan; Pachaiappan, Raman; Rajagopal, Rajakrishnan; Kuppusamy, Palaniselvam; Juliet, Annie; Arockiaraj, Jesu

doi:10.1016/j.scitotenv.2022.160968

Cited by 25 publications

(5 citation statements)

References 87 publications

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“…Other studies have also reported that syringol shows toxicity effects in vitro and in vivo in the concentration range of 0.5–2 ppm. 108 Additionally, Hs exhibits potential to induce mutations in the body ( M = 0.53), which is not observed in other syringol derivatives. Considering all these factors, apart from their potential as safe antioxidants, compounds like HAs, HPns, and HPs can be further investigated as specific neuroprotective agents.…”

Section: Resultsmentioning

confidence: 97%

Theoretical insight of reactive oxygen species scavenging mechanism in lignin waste depolymerization products

Rusdipoetra,

Suwito,

Puspaningsih

et al. 2024

RSC Adv.

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Section: Resultsmentioning

confidence: 97%

Theoretical insight of reactive oxygen species scavenging mechanism in lignin waste depolymerization products

Rusdipoetra,

Suwito,

Puspaningsih

et al. 2024

RSC Adv.

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“…The zebrafish serves as a cost‐effective and highly prolific in vivo toxicity test model, with a short reproductive cycle and easy observability. [ 56‐59 ] Notably, the 86.6% homology between zebrafish and human genes implies that experimental findings may have significant implications for human health. [ 60 ]…”

Section: Resultsmentioning

confidence: 99%

“…The zebrafish serves as a cost-effective and highly prolific in vivo toxicity test model, with a short reproductive cycle and easy observability. [56][57][58][59] Notably, the 86.6% homology between zebrafish and human genes implies that experimental findings may have significant implications for human health. [60] Given the heightened susceptibility of zebrafish embryos to environmental stressors during early developmental stages, we elected to utilize this life stage to investigate the potential developmental toxicity and teratogenic effects of F-sGOs.…”

Section: Developmental Toxicity and Teratogenic Effects Evaluation Of...mentioning

confidence: 99%

Structurally Optimized Fluorinated Small‐Sized Graphene Oxide for Enhanced Magnetic Resonance Imaging during Pregnancy

Xu,

Chen,

Wang

et al. 2023

Adv Funct Materials

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Gadolinium‐based complex contrast agents (GBCAs), frequently applied in magnetic resonance imaging (MRI), are associated with severe acute anaphylactic shock and incurable nephrogenic systemic fibrosis. Besides, the repeated use of GBCAs may result in the accumulation in various tissues. Given these potential adverse effects, GBCAs have not been well used during pregnancy. Herein, a novel metal‐free T2‐weighted MRI nanoprobe, designated fluorinated small‐sized graphene oxide with optimized fluorine content (LF‐sGO), is developed via graphene oxide materials. By introducing specific polar C─F bonds onto the small‐sized graphene oxide (sGO) skeleton, the prepared nanoprobe exhibits excellent water solubility, as well as superior MRI capabilities, thereby furnishing high‐resolution MRI anatomical information. Furthermore, the free radicals on LF‐sGO stabilized by C─F bonds confer LF‐sGO enrichment in the tumor region, enabling comprehensive imaging capability. The cytotoxicity study in vitro indicates that LF‐sGO has the potential to serve as a biocompatible imaging probe. Moreover, detailed in vivo studies on pregnant mice and zebrafish adequately demonstrate that microinjection of LF‐sGO does not induce dysontogensis and teratogenesis. This study successfully showcases a metal‐free nanoprobe that exhibits exceptional MRI capabilities for the purpose of tumor diagnosis. Notably, this nanoprobe holds promise for safe and effective tumor diagnosis during pregnancy.

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“…The anaesthetized zebrafish were fixed overnight in 1% formaldehyde and dehydrated using 80%, 90%, 95%, 100% ethanol, and 100% xylene. Dehydrated samples were embedded in paraffin and subjected to histology analysis [ 30 , 31 , 32 , 33 ]. Samples were sectioned and stained with haematoxylin and eosin, and the ocular regions were focused under a microscope.…”

Section: Methodsmentioning

confidence: 99%

Ophthalmic Intervention of Naringenin Decreases Vascular Endothelial Growth Factor by Counteracting Oxidative Stress and Cellular Damage in In Vivo Zebrafish

Sudhakaran,

Chandran,

Sreekutty

et al. 2023

Molecules

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Diabetes Mellitus is a metabolic disease that leads to microvascular complications like Diabetic retinopathy (DR), a major cause of blindness worldwide. Current medications for DR are expensive and report multiple side effects; therefore, an alternative medication that alleviates the disease condition is required. An interventional approach targeting the vascular endothelial growth factor (VEGF) remains a treatment strategy for DR. Anti-VEGF medicines are being investigated as the main therapy for managing vision-threatening complications of DR, such as diabetic macular oedema. Therefore, this study investigated the effect of flavonoid naringenin (NG) from citrus fruits on inhibiting early DR in zebrafish. When exposed to 130 mM glucose, the zebrafish larvae developed a hyperglycaemic condition accompanied by oxidative stress, cellular damage, and lipid peroxidation. Similarly, when adult zebrafish were exposed to 4% Glucose, high glucose levels were observed in the ocular region and massive destruction in the retinal membrane. High glucose upregulated the expression of VEGF. In comparison, the co-exposure to NG inhibited oxidative stress and cellular damage and restored the glutathione levels in the ocular region of the zebrafish larvae. NG regressed the glucose levels and cellular damage along with an inhibition of macular degeneration in the retina of adult zebrafish and normalized the overexpression of VEGF as a promising strategy for treating DR. Therefore, intervention of NG could alleviate the domestication of alternative medicine in ophthalmic research.

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Syringol, a wildfire residual methoxyphenol causes cytotoxicity and teratogenicity in zebrafish model

Cited by 25 publications

References 87 publications

Theoretical insight of reactive oxygen species scavenging mechanism in lignin waste depolymerization products

Theoretical insight of reactive oxygen species scavenging mechanism in lignin waste depolymerization products

Structurally Optimized Fluorinated Small‐Sized Graphene Oxide for Enhanced Magnetic Resonance Imaging during Pregnancy

Ophthalmic Intervention of Naringenin Decreases Vascular Endothelial Growth Factor by Counteracting Oxidative Stress and Cellular Damage in In Vivo Zebrafish

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