Syringomatous adenoma of the nipple: a case report

Abstract

IntroductionSyringomatous adenoma of the nipple is a very rare benign tumor. To the best of our knowledge, there are no reports of a syringomatous adenoma of the nipple metastasizing, although these tumors are known to infiltrate locally and to recur if not totally resected.Case presentationOur patient was a 41-year-old Japanese woman who complained of stiffness of her right nipple with abnormal discharge. Local resection of the tumor was performed. The pathological diagnosis was syringomatous adenoma of the nipple, and the resection margin was found to be positive. Accordingly, additional resection was recommended, but our patient did not allow another operation. After 1.5 years of careful follow-up, no local recurrence or distant metastasis has been observed.ConclusionThe optimal initial management of syringomatous adenoma of the nipple demands complete resection with histologically negative margins. However, from a cosmetic viewpoint, nipple-sparing resection could represent an alternative option for the treatment of syringomatous adenoma of the nipple.

Syringomatous Adenoma of the Nipple in a Male Breast: A Case Report With a Brief Review of Literature and Histomorphological Approach to Diagnosis

“…When it comes to low-grade adenosquamous carcinoma, differential diagnosis is not always easy to make. Therefore, we believe and agree with Rosen and others, who asserts unequivocally that despite certain anatomical similarities, the neoplastic processes of the two lesions are not the same [4][5][6][7][8][9][10][11][12][13][14][15][16]. Low-grade ASC of the breast is a low-grade form of metaplastic carcinoma of the breast with signs of metastasis [15], whereas SA of the nipple is benign and does not metastasize.…”

“…According to our information, in medical literature, only 38 instances of SAN have been documented, including 36 female cases and two male cases [ 5 - 9 ]. Such patients varied in age from 11 to 87 years old, with a mean age of 46.1 years at presentation [ 9 ]. The size range of the removed tumors varies from 5 to 40 mm in diameter, with an average of 17.7 mm [ 9 ].…”

“…Such patients varied in age from 11 to 87 years old, with a mean age of 46.1 years at presentation [ 9 ]. The size range of the removed tumors varies from 5 to 40 mm in diameter, with an average of 17.7 mm [ 9 ]. On two occasions, bilaterality was established [ 10 , 11 ].…”

“…The cut surface is uniformly grey or white with cystic areas. The areolar skin and breast tissue underneath are usually unremarkable [ 4 , 9 , 12 ].…”

Syringomatous Tumour Presenting as Inversion of a Supernumerary Nipple

“…SyT can present with symptoms such as a firm palpable mass in relation to the nipple, discharge, or inversion of the nipple [1, 2]. In general, SyT has previously been described in association to the nipple of the normal breast [7–11]. Only two previously published cases describe SyT in supernumerary breast tissue: a woman with SyT in supernumerary breast tissue that became symptomatic due to physiological changes during pregnancy [12] and one other case describing a young girl who had a supernumerary nipple removed for cosmetic reasons, where SyT was an accidental finding during microscopic examination [13].…”