Syringomatous adenoma of the nipple: A case report

Abstract

Syringomatous adenoma of the nipple is a rare disease. To our knowledge, only 23 cases have been reported in the literature. We present the case of a 36-year-old lactating woman with syringomatous adenoma of the nipple, in whom local excision of the tumor was performed. Histologically, the tumor consisted of tubules, ductules and epithelial cell strands, and most of the proliferating ducts showed a characteristic teardrop or comma-shaped appearance. Careful monitoring to detect local recurrence is considered necessary, because syringomatous adenoma of the nipple, while being benign, is a locally invasive tumor.

A Case of Syringomatous Adenoma of the Nipple

“…SAN is a locally infiltrative tumor that does not cause distant metastasis; however, recurrence has been reported in cases of incomplete excision [2, 3, 4, 5, 6, 7]. …”

Syringomatous adenoma of the nipple occurring within a supernumerary breast: a case report

“…These tumors are usually amenable to local excision, and they can persist or recur if incompletely excised. Relative few cases have been reported in the world literature (about 30), and no reports exist, to our knowledge, of any of these lesions occurring in a supernumerary breast 10,14–23 …”

Syringomatous Adenoma of the Nipple-Treatment by Central Mound Resection and Oncoplastic Reconstruction

“…Florid papillomatosis is a hyperplastic proliferation of ductal epithelium with a range of histologic appearances from mainly papillomatous to adenosis‐like. There can be compression of the ductal structures at the margin of the florid papillomatosis and it may give the impression of the tear‐shaped ducts of SA (11). Patients with florid papillomatosis tend to have more nipple erosion with bleeding, and also tend to be older (2).…”

“…They generally arise in the nipple and subsequently involve the underlying breast parenchyma (2). There have been a total of 31 cases reported in the English literature (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). All but one case occurred in females with an age range of 11-76 years.…”

“…SA also lacks spindle cell or osteocartilaginous metaplasia. Low-grade adenosquamous carcinoma has true malignant potential and an ability to metastasize, but SA is not known to metastasize and is only locally aggressive (11). SA has also been compared to microcystic adnexal carcinoma (MAC).…”