Syringotropic mycosis fungoides: Clinical and histologic features, response to treatment, and outcome in 19 patients

Masson, Adèle de; Battistella, Maxime; Vignon‐Pennamen, Marie‐Dominique; Cavelier‐Balloy, B.; Mouly, F.; Rybojad, M.; Bouaziz, Jean‐David; Petit, Antoine; Saussine, A.; Ronceray, S.; Gall, François Le; Ram‐Wolff, Caroline; Assouly, P.; Dereure, O.; Joly, P.; Dallot, A.; Dupuy, Alain; Lebbe, Célèste; Moulonguet, Isabelle; Rivet, Jacqueline; Janin, Anne; Bagot, M.

doi:10.1016/j.jaad.2014.06.033

Cited by 41 publications

(50 citation statements)

References 22 publications

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“…7 In the literature, there is only 1 case report include folliculotropic MF mimicking alopecia areata. 8 Contrary to limited alopesic patch in the latter case, alopesic patches and atrophic erythematous plaques were more and spreaded to other body areas very quickly in our case. In a previous study, 1550 MF patients were reviewed and only 5 patients had documented alopecia before or within 1 year of onset of skin symtoms.…”

Section: Discussioncontrasting

confidence: 59%

Folliculotropic Mycosis Fungoides Associated with Alopecia in a Case

Balevi¹,

Özdemır²,

Üstüner³

et al. 2017

Turkiye Klinikleri J Dermatol

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Section: Discussioncontrasting

confidence: 59%

Folliculotropic Mycosis Fungoides Associated with Alopecia in a Case

Balevi¹,

Özdemır²,

Üstüner³

et al. 2017

Turkiye Klinikleri J Dermatol

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“…In contrast, the anatomic distribution of lesions in STMF differs from that of classic MF, demonstrating a predisposition towards the extremities and palms/soles. 6 Men are affected twice as often as women with the youngest case reported a 19-year-old in China 11 and the oldest an 86-year-old in France (mean age 55). 6 …”

Section: Discussionmentioning

confidence: 99%

“…5 In the largest case-series of STMF published to date, de Masson et al found five-year disease specific survival approached 100% for STMF (n = 19) versus 74% individuals with FMF (n = 54). 6 …”

Section: Introductionmentioning

confidence: 99%

Syringotropic Mycosis Fungoides: A Rare Form of Cutaneous T-cell Lymphoma Enabling a Histopathologic “Sigh of Relief”

Lehmer¹,

Amber

Feraudy

2017

The American Journal of Dermatopathology

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Syringotropic mycosis fungoides (STMF) is a very rare variant of cutaneous T-cell lymphoma (CTCL). It follows a much milder disease course than its clinically indistinguishable adnexal counterpart, folliculotropic mycosis fungoides (FMF). We report a case of a 36-year-old male who presented with erythematous, studded papules and plaques on the left upper extremity and right anterior thigh diagnosed as MF Stage 1A on initial superficial shave biopsy. Lesions recurred after initial improvement with narrow band ultraviolet light therapy demonstrating a concentration of abnormal lymphocytes around eccrine sweat glands on repeat biopsy, consistent with STMF. While the deeper, periadnexal infiltrate found in both STMF and FMF confers increased resistance to skin-directed therapies effective in classic MF, these entities diverge with respect to their clinical behavior. Syringotropism is a marker for increased disease specific survival whereas even FMF carries a prognosis worse than conventional MF. Increased awareness amongst the dermatopathology community of the histopathologic distinction between STMF and FMF is essential to guide treatment type, duration, and intensity in adnexal disease.

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“…Epidermotropism is prominent (up to 84%), unlike in FMF where epidermotropism is the exception to the rule. Follicular involvement is seen in up to 68% of cases, and follicular mucinosis in 15–32% of patients 12 . Immunohistochemistry reveals a CD4+ T-helper cell immunophenotype.…”

Section: Non-who/eortc Variantsmentioning

confidence: 99%

Unusual variants of mycosis fungoides

Virmani¹,

Myskowski²,

Pulitzer³

2016

Diagnostic Histopathology

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Conventional presentations of mycosis fungoides may be diagnostically challenging, particularly in light of the controversial boundaries defining the disease. Variant presentations of this cutaneous T-cell lymphoma add a further layer of complexity, requiring a sophisticated and informed perspective when evaluating lymphoid infiltrates in the skin. Herein we discuss well-defined (WHO-EORTC) variants pagetoid reticulosis, granulomatous slack skin and folliculotropic mycosis fungoides as well as less well-defined morphologic/architectural variants, and divergent immunohistochemical presentations of this typically indolent T-cell lymphoproliferative disease.

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Syringotropic mycosis fungoides: Clinical and histologic features, response to treatment, and outcome in 19 patients

Cited by 41 publications

References 22 publications

Folliculotropic Mycosis Fungoides Associated with Alopecia in a Case

Folliculotropic Mycosis Fungoides Associated with Alopecia in a Case

Syringotropic Mycosis Fungoides: A Rare Form of Cutaneous T-cell Lymphoma Enabling a Histopathologic “Sigh of Relief”

Unusual variants of mycosis fungoides

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