Case RePORTCOVID-19 positive case in the past 10 days. Her vitals were pulsed 78/min, BP 110/70 mm Hg, temp 100°F with the respiratory rate (RR) 26/min, and oxygen saturation (SpO 2 ) 96% on room air. Crepitations were present in the left lower zone on chest auscultation. Her initial investigations were hemoglobin (Hb) 7.1 g/dL, total leucocyte count (TLC) 7090/µL with 65% neutrophils, and platelets 2.74 lakh/µL. Her renal and liver function tests and urinalysis and electrocardiographic (ECG) were within normal limits (WNL) except for serum bilirubin 1.4 mg/dL (conjugated 0.5 mg/dL and unconjugated 0.9 mg/dL). Her chest X-ray (CXR) suggested of left lower zone pneumonia and arterial blood gases (ABG) showed pH 7.47, pO 2 72.9 mm Hg, pCO 2 35 mm Hg, bicarbonate-25.2 mmol/L. She was started on oxygen (O 2 ) by face mask, oral paracetamol, HCQ, and intravenous (IV) cefoperazone-sulbactam. On day 2 of admission, she became restless, agitated, and breathless with falling SpO 2 (85%). She was immediately intubated and kept on mechanical ventilation. Her immediate postintubation ABG showed pH 7.34, PaCO 2 50 mm Hg, PaO 2 132 mm Hg [fraction of inspired oxygen (FiO 2 ) 100%], bicarbonate 26 mmol/L. Her COVID-19 RT-PCR, Typhidot, and malaria antigen test reports were negative. Her Hb further dropped to 5.6 gm/dL on day 4 of admission, for which two units of packed red blood cells (PRBC) were transfused. Her TLC increased to 17,540/µL with 84% neutrophils and worsening of CXR. Her endotracheal aspirate grew pseudomonas resistant A 28-year-old female presented with complaints of high-grade fever with chills for five days and a history of contact with a 1,