Direct methanol fuel cell is a complex nonlinear system, which is difficult to establish accurate mathematical model and control. In this article, we use state-space model to analyze this system. In terms of application, we make use of multi-variable fuzzy control theory and design a parameter adaptive fuzzy PID controller to solve some problems such as time variation and uncertainty in system control. Finally, we use Matlab software to simulate it, and the simulation results show that the control system solution can improve the performance of DMFC, and this solution is reasonable and effective.