With technology scaling the susceptibility of circuits to different reliability degradations is steadily increasing. Aging in transistors due to Bias Temperature Instability (BTI) and voltage fluctuation in the power delivery network of circuits due to IR-drops are the most prominent. In this work, we are reporting for the first time, that there are interdependencies between voltage fluctuation and BTI aging, that are non-negligible. Modeling and investigating the joint impact of voltage fluctuation and BTI aging on the delay of circuits, while remaining compatible with the existing standard design flow, is indispensable in order to answer the vital question, "What is an efficient (i.e. small, yet sufficient) timing guardband to sustain the reliability of circuit for the projected lifetime?" This is, concisely, the key goal of this paper. Achieving that would not be possible without employing a physics-based BTI model that precisely describes the underlying generation and recovery mechanisms of defects under arbitrary stress waveforms. For this purpose, our model is validated against varied semiconductor measurements covering a wide range of voltage, temperature, frequency and duty cycle conditions.To bring reliability awareness to existing EDA tool flows, we create standard cell libraries that contain the delay information of cells under the joint impact of aging and IR-drop. Our libraries can be directly deployed within the standard design flow because they are compatible with existing commercial tools (e.g., Synopsys and Cadence). Hence, designers can leverage the mature algorithms of these tools to accurately estimate the required timing guardbands for any circuit despite its complexity. Our investigation demonstrates that considering aging and IRdrop effects independently, as done in state of the art, leads to employing insufficient and thus unreliable guardbands because of the non-negligible (on average 15% and up to 25%) underestimations. Importantly, considering interdependencies between aging and IR-drop does not only allow correct guardband estimations but it also results in employing more efficient guardbands.