Systematic altering of semiflexible DNA-based polymer networks <i>via</i> tunable crosslinking

Gläser, Martin; Mollenkopf, Paul; Prascevic, Dusan; Ferraz, Catarina; Käs, Josef A.; Schnauß, Jörg; Smith, David M.

doi:10.1039/d2nr05615a

Cited by 4 publications

(1 citation statement)

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“…54,55 The revealed dynamic/reversibility structures and performances of the hierarchical network structures at a long range might also be useful for designing and programming mesoscopic structural networks for new-generation biomaterial devices. 56–59 Furthermore, the identification of the major hierarchical structures driven by physiological needs to induce specific complex architectures, not of random organization, guarantees control over the extracellular network of macroscopic structures, especially for the relevant outer profile having the first impact with the external biological identity. 60 Furthermore, the novel structural approaches adopted here not only give us the advantage of characterizing self-assembling glycoprotein surface/networks but also the feasibility of applying these morpho-structural studies to any complex system, independently of the dimension scale.…”

Section: Discussionmentioning

confidence: 99%

Self-assembly of glycoprotein nanostructured filaments for modulating extracellular networks at long range

Matassa,

Gatti,

Crociati

et al. 2023

Nanoscale

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Section: Discussionmentioning

confidence: 99%

Self-assembly of glycoprotein nanostructured filaments for modulating extracellular networks at long range

Matassa,

Gatti,

Crociati

et al. 2023

Nanoscale

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A Science Friction Story: Molecular Interactions in Semiflexible Polymer Networks

Mollenkopf,

Prascevic,

Glaser

et al. 2024

Adv Materials Inter

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Established model theories, developed to capture the mechanical behavior of soft, complex materials composed of semiflexible polymers, assume that entropic interactions between filaments are primarily responsible for determining the mechanical response. In recent studies, the generally accepted tube model has been challenged in terms of this basic assumption about filament–filament interactions, but also because of its predictions regarding the frequency dependence of the elastic modulus in the intermediate frequency regime. A central question is how molecular interactions and friction between network constituents influence the rheological response of isotropic entangled networks of semiflexible polymers. It has been previously shown that friction forces between aligned pairs of actin filaments are not negligible. Here, the influence of friction forces and attractive interactions on network rheology is systematically investigated by means of targeted surface modification. It is shown that these forces have a qualitative and quantitative influence on the viscoelastic properties of semiflexible polymer networks and contribute to their response to nonlinear deformations. By comparing two polymer model systems with respect to their surface compositions, a possible explanation is given about the origin of acting forces on a molecular level.

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Why Biopolymer Microgels with Dynamically Switchable Properties Would be a Great Tool‐Box for the Cultivation of Stem Cells

Özkale,

Lieleg

2024

Adv Materials Inter

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In this short perspective article, it is asked why – different from their macroscopic bulk counterparts – biopolymer‐based microgels with dynamically switchable mechanical properties are basically non‐existent. The article pinpoints why such dynamic control over the viscoelasticity of microgels would be desirable for the encapsulation of stem cells, how switchable mechanical properties may be achievable in biopolymer‐based microgel systems, and what pitfalls and issues need to be addressed to realize such a complex, engineered microenvironment for cells.

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Systematic altering of semiflexible DNA-based polymer networks via tunable crosslinking

Abstract: In order to understand and predict the mechanical behaviors of complex, soft biomaterials such as cells or stimuli-responsive hydrogels, it is important to connect how the nanoscale properties of their...

Cited by 4 publications

References 47 publications

Self-assembly of glycoprotein nanostructured filaments for modulating extracellular networks at long range

Self-assembly of glycoprotein nanostructured filaments for modulating extracellular networks at long range

A Science Friction Story: Molecular Interactions in Semiflexible Polymer Networks

Why Biopolymer Microgels with Dynamically Switchable Properties Would be a Great Tool‐Box for the Cultivation of Stem Cells

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