Abstract:Patients with cancer may be given treatments that are not officially approved (off-label) or recommended by guidelines (off-guideline) for multiple reasons including a lack of effective approved treatments. Here we present a systematic characterization of the patterns of off-label and off-guideline usage in 153,122 U.S. patients with 14 common cancer types using a large electronic health record (EHR)-derived de-identified database. We find that 18.3% and 3.9% of patients have received at least one line of off-… Show more
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