Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer

Karamitopoulou, Eva; Zlobec, Inti; Panayiotides, Ioannis G.; Patsouris, Efstratios; Peros, George; Rallis, Georgios; Lapas, Christos; Karakitsos, Petros; Terracciano, Luigi; Lugli, Alessandro

doi:10.1016/j.humpath.2010.06.020

Cited by 45 publications

(37 citation statements)

References 32 publications

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“…The analysis of primary tumors as the current gold standard for therapeutic decisions might be critical owing to intratumoral genetic heterogeneity (10,11 ) and increasing genomic instability during disease progression. This issue is further underlined by several reports showing discordant mutations (KRAS, BRAF, PIK3CA, TP53) between CRC primary tumors and corresponding metastasis in 5%-37% of patients (9,11,12 ).…”

Section: Discussionmentioning

confidence: 99%

Heterogeneity of Epidermal Growth Factor Receptor Status and Mutations of KRAS/PIK3CA in Circulating Tumor Cells of Patients with Colorectal Cancer

Bauernhofer²,

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Heterogeneity of Epidermal Growth Factor Receptor Status and Mutations of KRAS/PIK3CA in Circulating Tumor Cells of Patients with Colorectal Cancer

Bauernhofer²,

et al. 2013

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“…2AeB. When comparing the tumor center with the invasive front, CDX2 protein expression was significantly lower at the invasive front [30].…”

Section: Expression Studiesmentioning

confidence: 94%

The clinical perspectives of CDX2 expression in colorectal cancer: A qualitative systematic review

et al. 2014

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“…Although several CRC studies have described the overexpression of MMP7 (Akishima-Fukasawa et al, 2011;Karamitopoulou et al, 2011;Nastase et al, 2011;Bujanda et al, 2013), a relationship between the MMP7-181A/G polymorphism and MMP7 overexpression in CRC patients remains to be verified.…”

Section: Association Analysismentioning

confidence: 97%

Association of MMP7-181A/G and MMP13-77A/G polymorphisms with colorectal cancer in a Mexican population

et al. 2014

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ABSTRACT. Colorectal cancer (CRC) is characterized by enhanced expression and activity of several metalloproteinases (MMPs), including MMP13 and MMP7, which play an important role in tumor Genomic DNA samples were obtained from peripheral blood of 102 CRC patients and 125 blood donors who were included as the control group. Identification of polymorphisms was based on polymerase chain reaction-restriction fragment length polymorphism methodology. The association was estimated by the odds ratio (OR) test. The results showed that MMP7-181A/G and MMP13-77A/G variants were associated with CRC. For MMP7-181A/G, the AA (P = 0.02, OR = 3.38, 95% confidence interval (CI) = 1.16-9.84) and AG (P = 0.01, OR = 3.4, 95%CI = 1.17-9.83) genotypes were associated with an increased risk of CRC. For MMP13-77A/G, the AA and AG genotypes were associated with CRC (AA genotype: P = 0.04, OR = 3.2, 95%CI = 1.004-10.2; AG genotype: P = 0.01, OR = 4.08, 95%CI = 1.3-13.07). In conclusion, AA and AG genotype carriers for both polymorphisms are at a higher risk of developing CRC in this Mexican population.

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Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer

Cited by 45 publications

References 32 publications

Heterogeneity of Epidermal Growth Factor Receptor Status and Mutations of KRAS/PIK3CA in Circulating Tumor Cells of Patients with Colorectal Cancer

Heterogeneity of Epidermal Growth Factor Receptor Status and Mutations of KRAS/PIK3CA in Circulating Tumor Cells of Patients with Colorectal Cancer

The clinical perspectives of CDX2 expression in colorectal cancer: A qualitative systematic review

Association of MMP7-181A/G and MMP13-77A/G polymorphisms with colorectal cancer in a Mexican population

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