Systematic Analysis of tRNA-Derived Small RNAs Discloses New Therapeutic Targets of Caloric Restriction in Myocardial Ischemic Rats

Liu, Wenjing; Liu, Yang; Pan, Zhaohai; Zhang, Xin; Qin, Yao Jun; Chen, Xiaojie; Li, Minjing; Chen, Xiaoyu; Zheng, Qiusheng; Liu, Xiaona; Li, Defang

doi:10.3389/fcell.2020.568116

Cited by 25 publications

(14 citation statements)

References 45 publications

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“…Both tRFs & tiRNAs have also been identified as a novel biomarker for the treatment of skin melanoma ( Zheng et al, 2016 ). Other studies have shown that tsRNAs are potential therapeutic targets for caloric restriction pretreatment to improve myocardial ischemic injury ( Liu et al, 2020 ). Moreover, tsRNA is a potential therapeutic target for Buyang-Huanwu-Decoction (BYHWD) in the treatment of intracerebral hemorrhage (ICH), which provides new insights into the mechanism by which BYHWD promotes neural function recovery after ICH ( Li et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Differential Expression Profiles and Function Predictions for tRFs & tiRNAs in Skin Injury Induced by Ultraviolet Irradiation

Fang

Liu

Yan

et al. 2021

Front. Cell Dev. Biol.

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Ultraviolet (UV) radiation is a major environmental factor contributing skin damage. As UV exposure is inevitable, it is necessary to pay attention to the underlying molecular mechanisms of UV-induced skin damage to develop effective therapies. tRNA-derived stress-induced RNAs (tiRNAs) and tRNA-derived fragments (tRFs) are tRNA-derived small RNAs (tsRNAs) that are a novel class of short, non-coding RNAs. However, the functions behind tRFs & tiRNAs in UV-induced skin injury are not yet clear. Firstly, the animal model of ultraviolet irradiation induced skin damage was established. Then the skin samples were preserved for the follow-up experiment. Sequencing was used to screen expression profiles and predict target genes. Compared with normal skin, a total of 31 differentially expressed tRFs & tiRNAs were screened. Among these, 10 tRFs & tiRNAs were shown to be significantly different in expression levels, where there were 4 up-regulated and 6 down-regulated target genes. Bioinformatics analyses revealed potential up-regulated tsRNAs (tRF-Val-AAC-012, tRF-Pro-AGG-012, tRF-Val-CAC-018, tRF-Val-AAC-031) and down-regulated tsRNAs (tRF-Arg-CCT-002, tRF-Trp-TCA-001, tiRNA-Ser-GCT-001, tRF-Gly-CCC-019, tRF-Ala-TGC-001, tRF-Ala-TGC-002). In summary, it was speculated that tRF-Gly-CCC-019 plays an important role in acute skin injury induced by UVB radiation by regulating the ras-related C3 botulinum toxin substrate 1 (Rac1) gene in the WNT signaling pathway. This study provides new insights into the mechanisms and therapeutic targets of UV-induced skin injury.

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Section: Discussionmentioning

confidence: 99%

Differential Expression Profiles and Function Predictions for tRFs & tiRNAs in Skin Injury Induced by Ultraviolet Irradiation

Fang

Liu

Yan

et al. 2021

Front. Cell Dev. Biol.

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“…Existing studies have shown that tRFs and tiRNAs are highly conserved small ncRNAs fragments playing important roles in physiological and pathological conditions, such as development, 29 ageing, 30 neurodegenerative diseases, 31 cancer 32 , 33 , 34 and cardiovascular diseases. 35 Hence, they serve as rational therapeutic targets. 36 In the current study, it was hypothesized that differential expression of tRFs and tiRNAs play an essential role in the development of AS.…”

Section: Discussionmentioning

confidence: 99%

Expression profiles and potential roles of transfer RNA‐derived small RNAs in atherosclerosis

Yang

Wang

et al. 2021

J Cellular Molecular Medi

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Atherosclerosis (AS), one of the most common cardiovascular diseases, is the primary cause of morbidity and mortality in the case of cardiac events, thus posing a great threat to human health worldwide. [1][2][3] The disease is characterized by deposition of lipid and other blood components in the intima of the artery, proliferation of smooth muscle cells and increase of collagen fibres, chronic inflammation, plaque formation and hardening of the vascular walls. [3][4][5] The development of atheromatous plaques leads to serious clinical outcomes. 6,7 Once the vulnerable plaques rupture, they induce several clinical conditions, including stroke and myocardial infarction. 8 To date, arteriography is considered to be the gold standard for the diagnosis of AS. However, given the involvement of an invasive procedure, primary injury is

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“…The severity of the disease is divided into mild, moderate and severe, according to guidance for COVID-19 pneumonia diagnosis and treatment plan in China. Fold-change > 1.5 and P-value < 0.05 was used as the selection criteria [ 25 , 26 ]. Finally, we analyzed the potential clinical application value of autophagy-related genes identified in this study for evaluating the different disease severities of COVID-19 patients.…”

Section: Methodsmentioning

confidence: 99%

Construction of an autophagy interaction network based on competitive endogenous RNA reveals the key pathways and central genes of SARS-CoV-2 infection in vivo

Chen

Wang

et al. 2021

Microbial Pathogenesis

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As of April 1, 2021, more than 2.8 million people have died of SARS-CoV-2 infection. In addition, the mutation of virus strains that have accompanied the pandemic has brought more severe challenges to pandemic control. Host microRNAs (miRNAs) are widely involved in a variety of biological processes of coronavirus infection, including autophagy in SARS-CoV-2 infection. However, the mechanisms underlying miRNAs involved in autophagy in SARS-CoV-2 infection have not been fully elucidated. In this study, the miRNA and messenger RNA (mRNA) expression profiles of patients with SARS-CoV-2 infection were investigated based on raw data from Gene Expression Omnibus (GEO) datasets, and potential novel biomarkers of autophagy were revealed by bioinformatics analyses. We identified 32 differentially expressed miRNAs and 332 differentially expressed mRNAs in patients with SARS-CoV-2 infection. Cytokine receptor related pathways were the most enriched pathways for differentially expressed miRNAs identified by pathway analysis. Most importantly, an autophagy interaction network, which was associated with the pathological processes of SARS-CoV-2 infection, especially with the cytokine storm, was constructed. In this network, hsa-miR-340–3p, hsa-miR-652–3p, hsa-miR-4772–5p, hsa-miR-192–5p, TP53INP2, and CCR2 may be biomarkers that predict changes in mild SARS-CoV-2 infection. Some molecules, including hsa-miR-1291 and CXCR4, were considered potential targets to predict the emergence of severe symptoms in SARS-CoV-2 infection. To our knowledge, this study provided the first profile analysis of an autophagy interaction network in SARS-CoV-2 infection and revealed several novel autophagy-related biomarkers for understanding the pathogenesis of SARS-CoV-2 infection in vivo.

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Systematic Analysis of tRNA-Derived Small RNAs Discloses New Therapeutic Targets of Caloric Restriction in Myocardial Ischemic Rats

Cited by 25 publications

References 45 publications

Differential Expression Profiles and Function Predictions for tRFs & tiRNAs in Skin Injury Induced by Ultraviolet Irradiation

Differential Expression Profiles and Function Predictions for tRFs & tiRNAs in Skin Injury Induced by Ultraviolet Irradiation

Expression profiles and potential roles of transfer RNA‐derived small RNAs in atherosclerosis

Construction of an autophagy interaction network based on competitive endogenous RNA reveals the key pathways and central genes of SARS-CoV-2 infection in vivo

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