Systematic and Endothelial Inflammation and Endothelial Progenitor Cell Levels in Emphysematous Rats Exposed to Intermittent Hypoxia

Yang, Qianyu; Sun, Xin; Wang, Yongmei; Wu, Qi; Feng, Jing; Chen, Bao-yuan

doi:10.4187/respcare.03492

Cited by 11 publications

(10 citation statements)

References 38 publications

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“…Endothelial progenitor cells (EPCs) act to repair endothelial injury and replace dysfunctional endothelium after being mobilized from the bone marrow to circulating blood [96]. Therefore, circulating EPCs provide a way to monitor endothelial damage.…”

Section: Introductionmentioning

confidence: 99%

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The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

Green

Turner

2017

Respir Res

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COPD and asthma are important chronic inflammatory disorders with a high associated morbidity. Much research has concentrated on the role of inflammatory cells, such as the neutrophil, in these diseases, but relatively little focus has been given to the endothelial tissue, through which inflammatory cells must transmigrate to reach the lung parenchyma and cause damage. There is evidence that there is an abnormal amount of endothelial tissue in COPD and asthma and that this tissue and its’ progenitor cells behave in a dysfunctional manner. This article reviews the evidence of the involvement of pulmonary endothelium in COPD and asthma and potential treatment options for this.

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Section: Introductionmentioning

confidence: 99%

“…Therefore, circulating EPCs provide a way to monitor endothelial damage. Animal studies have demonstrated that EPC levels are increased in rat models of emphysema in comparison to controls [96]. Conversely, in human studies, COPD patients appear to have reduced numbers of EPCs compared to controls [97].…”

Section: Introductionmentioning

confidence: 99%

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

Green

Turner

2017

Respir Res

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“…Our acute model further allowed us to evaluate the early effects of these injurious stimuli while avoiding other confounding factors found in OSA patients which also cause inflammation and endothelial dysfunction, such as metabolic syndrome, obesity, and hypertension. 29 However, this model ignores anatomical site of upper airway obstruction, and does not take into account the effects of animal sleep and arousal on blood oxygen levels. Nevertheless, these factors would not influence the primary focus of our study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Antioxidant Tempol on Systematic Inflammation and Endothelial Apoptosis in Emphysematous Rats Exposed to Intermittent Hypoxia

Zhao

et al. 2018

Yonsei Med J

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PurposeObstructive sleep apnea and chronic obstructive pulmonary disease are independent risk factors of cardiovascular disease (CVD), and their coexistence is known as overlap syndrome (OS). Endothelial dysfunction is the initial stage of CVD; however, underlying mechanisms linking OS and CVD are not well understood. The aim of this study was to explore whether OS can lead to more severe inflammation and endothelial apoptosis by promoting endothelial dysfunction, and to assess the intervention effects of antioxidant tempol.Materials and MethodsMale Wistar rats (n=66) were exposed to normal oxygen [normal control (NC) group], intermittent hypoxia (IH group), cigarette smoke (CH group), as well as cigarette smoke and IH (OS group). Tempol intervention was assessed in OS group treated with tempol (OST group) or NaCl (OSN group). After an 8-week challenge, lung tissues, serum, and fresh blood were harvested for analysis of endothelial markers and apoptosis.ResultsThe levels of intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, and apoptosis in circulating epithelial cells were the highest in OS group and the lowest in NC group. These levels were all greater in IH group than in CH group, and were lower in OST group than in OS and OSN groups (all p<0.001).ConclusionSynergistic effects of IH with cigarette smoke-induced emphysema produce a greater inflammatory status and endothelial apoptosis. OS-related inflammation and endothelial cell apoptosis may play important roles in promoting cardiovascular dysfunction, and antioxidant tempol could achieve a partial protective effect.

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“…It has long been demonstrated that circulating IL‐6 plays a pivotal role in early atherosclerosis and therefore is relevant to understand cardiovascular disease . Proinflammatory cytokines such as IL‐6 induce monocyte migration and are relevant for vascular smooth muscle cell proliferation and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Influence of antithymocyte globulin treatment of brain-dead organ donor on inflammatory response in cardiac grafts: an experimental study in mice

et al. 2016

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The expression of proinflammatory cytokines in donor hearts after antithymocyte globulin (ATG) treatment given prior to organ removal was evaluated to analyze changes in inflammatory response. Adult female OF-1 mice were randomized into brain death (BD) groups (BD Control, BD ATG) with or without treatment, and Controls (Control, ATG). BD induction was performed through gradual inflation of an intracranial positioned balloon catheter. At the end of a 6-h observation period, ATG (1 mg/kg BW) was given intravenously. After 45 min, the donor hearts were removed. Proinflammatory markers IL-2 and IL-6 were examined using ELISA and immunohistochemistry staining. After single administration of ATG, the inflammatory reaction in the myocardium showed a significant reduction in IL-2 expression (BD Control vs. BD ATG, P = 0.033). Our investigation showed expected increase in proinflammatory mediators after BD. This increase was abolished by single infusion of ATG, indicated by significant reduction in IL-2 levels in the myocardium. We observed a reduction of IL-6 deposition in media cells in ATG-treated specimens. Further research is necessary to evaluate the role of ATG in donor management considering a potentially positive effect of ATG on IL-2-directed inflammatory response and possible reduction of IL-6-mediated vascular changes.

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Systematic and Endothelial Inflammation and Endothelial Progenitor Cell Levels in Emphysematous Rats Exposed to Intermittent Hypoxia

Cited by 11 publications

References 38 publications

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

Effects of Antioxidant Tempol on Systematic Inflammation and Endothelial Apoptosis in Emphysematous Rats Exposed to Intermittent Hypoxia

Influence of antithymocyte globulin treatment of brain-dead organ donor on inflammatory response in cardiac grafts: an experimental study in mice

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