Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part III: Chromatographic Purification

Mestmäcker, Fabian; Schmidt, A.; Huter, Maximilian; Sixt, Maximilian; Strube, Jochen

doi:10.3390/pr6100180

Cited by 13 publications

(7 citation statements)

References 36 publications

(39 reference statements)

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“…Adsorption and chromatographic separation techniques allow the purification of complex mixtures. These techniques, in particular, are applied to the separation of pure compounds [72,82]. Crystallization is a separation technique which allows a separation of compounds based on their melting point or solubility [39,83].…”

Section: Technological Processing Of Biogenic Raw Materialsmentioning

confidence: 99%

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Process Engineering Accelerating an Economic Industrialization Towards a Bio-Based World

2019

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The transition towards a bio-based world is a challenging undertaking. This perspective paper, from an engineering point of view, aims to provide an overview of existing projects and academic disciplines highlighting the potential benefit of increased interdisciplinary exchanges. Furthermore, the current utilization of biomass to produce biogas is discussed, including an economic assessment, showing the need for new strategies of biomass valorization. One solution could be the development of separation processes for the isolation of secondary plant metabolites, which have been especially valuable for pharmaceutical applications, e.g., taxotere ® and artemisinin. The economic feasibility is demonstrated in a case study, evaluating the purification potential of curcuminoids from Curcuma longa L. Subsequently, the conclusion discusses the limitations of large-scale industrial applications and the need for new separation techniques as a step towards a bio-based world.

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Section: Technological Processing Of Biogenic Raw Materialsmentioning

confidence: 99%

“…Adsorption and chromatographic separation techniques allow the purification of complex mixtures. These techniques, in particular, are applied to the separation of pure compounds [72,82].…”

Section: Technological Processing Of Biogenic Raw Materialsmentioning

confidence: 99%

Process Engineering Accelerating an Economic Industrialization Towards a Bio-Based World

2019

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“…It can be concluded from this that the concentration shortly before leaving the discrete corresponds to the concentration shortly after leaving the discrete [28]. The change in concentration at the end of the balance sheet area can therefore be formulated, as shown in Equation (7):…”

Section: Distributed-plug-flow Modelmentioning

confidence: 99%

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part II: Model-Based Design of Agitated and Packed Columns for Multistage Extraction and Scrubbing

et al. 2018

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Liquid-liquid extraction (LLE) is an established unit operation in the manufacturing process of many products. However, development and integration of multistage LLE for new products and separation routes is often hindered and is probably more cost intensive due to a lack of robust development strategies and reliable process models. Even today, extraction columns are designed based on pilot plant experiments. For dimensioning, knowledge of phase equilibrium, hydrodynamics and mass transport kinetics are necessary. Usually, those must be determined experimentally for scale-up, at least in scales of DN50-150 (nominal diameter). This experiment-based methodology is time consuming and it requires large amounts of feedstock, especially in the early phase of the project. In this study the development for the integration of LLE in a new manufacturing process for artemisinin as an anti-malaria drug is presented. For this, a combination of miniaturized laboratory and mini-plant experiments supported by mathematical modelling is used. System data on extraction and washing distributions were determined by means of shaking tests and implemented as a multi-stage extraction in a process model. After the determination of model parameters for mass transfer and plant hydrodynamics in a droplet measurement apparatus, a distributed plug-flow model is used for scale-up studies. Operating points are validated in a mini-plant system. The mini-plant runs are executed in a Kühni-column (DN26) for extraction and a packed extraction column (DN26) for the separation of side components with a throughput of up to 3.6 L/h, yield of up to 100%, and purity of 41% in the feed mixture to 91% after washing.

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“…Nevertheless, any theory has to be validated experimentally for proper industrial decisions. Therefore, final model validation has been shown successfully by pilot studies for botanicals [28][29][30][31][32] and biologics [33]. Botanicals show the highest improvement potential by yield improvements (60-80%), organic solvent substitution (water-based pressurized hot water extraction (PHWE)) and solvent reduction by reducing the process time (factors 5-20) resulting in significant COGs (factors of two to 10) and GWP (factors of four to 20) reductions [27,33].…”

Section: Introductionmentioning

confidence: 99%

Technical Potential for Energy and GWP Reduction in Chemical–Pharmaceutical Industry in Germany and EU—Focused on Biologics and Botanicals Manufacturing

2020

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European policy demands climate neutrality by the year 2050. Therefore, any manufacturing optimization needs to be achieved in the well-known pareto of global warming potential (GWP) reduction combined with cost of goods (COG) reduction at increasing product amounts, while still being able to compete in the world market. The chemical–pharmaceutical industry is one of the most energy-intensive industries. The pharmaceutical industry operates with low batch sizes, but high margins. This study analyzes, based on the literature and Bundesministerium für Wirtschaft und Energie (BMWi; English: Federal Ministry for Economic Affairs and Energy)-funded project results, the technical potentials for energy and GWP reduction, while focusing on biologics and botanicals, because those are already widely based on natural raw material resources. The potential impact for green technologies is pointed out in relation to climate-neutral manufacturing.

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Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part III: Chromatographic Purification

Cited by 13 publications

References 36 publications

Process Engineering Accelerating an Economic Industrialization Towards a Bio-Based World

Process Engineering Accelerating an Economic Industrialization Towards a Bio-Based World

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part II: Model-Based Design of Agitated and Packed Columns for Multistage Extraction and Scrubbing

Technical Potential for Energy and GWP Reduction in Chemical–Pharmaceutical Industry in Germany and EU—Focused on Biologics and Botanicals Manufacturing

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