2023
DOI: 10.1101/2023.06.19.545563
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Systematic Characterization of LSD metabolites inC. elegansby ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry

Christiane Martins de Vasconcellos Silveira,
Vanessa Farelo dos Santos,
Isis Moraes Ornelas
et al.

Abstract: Psychedelic compounds have gained renewed interest for their potential therapeutic applications, but their metabolism and effects on complex biological systems remain poorly understood. Here, we present a systematic characterization of LSD metabolites in the model organismCaenorhabditis elegansusing state-of-the-art analytical techniques. By employing ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UHPLC-HRMS/MS), we identified and quantified a range of LSD m… Show more

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