Objectives
Preoperative testing for carotid endarterectomy (CEA) often includes blood typing and antibody screen (T&S). In our institutional experience, however, transfusion for CEA is rare. We assessed transfusion rate and risk factors in a national clinical database to identify a cohort of patients in whom T&S can safely be avoided with the potential for substantial cost savings.
Methods
Using the NSQIP database, transfusion events and timing were established for all elective CEAs in 2012–13. Comorbidities and other characteristics were compared for patients receiving intra- or postoperative transfusion and those that did not. After random assignment of the total data to either a training or validation set, a prediction model for transfusion risk was created and subsequently validated.
Results
Of 16,043 patients undergoing CEA in 2012–13, 276 received at least one transfusion prior to discharge (1.7%). 42% of transfusions occurred on the day of surgery. Preoperative hematocrit < 30% (Odds ration OR: 57.4; 95% confidence interval CI: 29.6–111.1), history of congestive heart failure (OR: 2.8; 95%CI: 1.1 – 7.1), dependent functional status (OR: 2.7; 95%CI: 1.5–5.1), coagulopathy (OR: 2.5; 95%CI: 1.7–3.6), creatinine ≥ 1.2 mg/dl (OR: 2.3; 95%CI: 1.6–3.3) preoperative dyspnea (OR: 2.0; 95%CI: 1.4–3.1) and female gender (OR: 1.6; 95%CI: 1.1–2.3) predicted transfusion. A risk prediction model based on these data produced a C-statistic of 0.85; application of this model to the validation set demonstrated a C-statistic of 0.81. 93% of patients in the validation set received a score of 6 or less corresponding to an individual predicted transfusion risk of 5% or less. Omitting a T&S in these patients would generate a substantial annual cost saving for NSQIP hospitals.
Conclusions
While T&S is commonly performed for patients undergoing CEA, transfusion following CEA is rare and well predicted by a transfusion risk score. Avoidance of T&S in this low-risk population provides a substantial cost-saving opportunity without compromise of patient care.