Systematic derivatization, mass fragmentation and acquisition studies in the analysis of chlorophenols, as their silyl derivatives by gas chromatography–mass spectrometry

Faludi, T.; Andrási, N.; Vasanits-Zsigrai, A.; Záray, Gy.; Molnár-Perl, I.

doi:10.1016/j.chroma.2013.06.004

Cited by 18 publications

(3 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evaluation is also based on our earlier experiences being deeply involved in the analysis of organics even as environmental pollutants [81][82][83][84][85].…”

Section: Sample and Methods Selectionmentioning

confidence: 99%

The role of derivatization techniques in the analysis of glyphosate and aminomethyl-phosphonic acid by chromatography

Arkan

Molnár-Perl

2015

Microchemical Journal

Self Cite

View full text Add to dashboard Cite

“…Evaluation is also based on our earlier experiences being deeply involved in the analysis of organics even as environmental pollutants [81][82][83][84][85].…”

Section: Sample and Methods Selectionmentioning

confidence: 99%

The role of derivatization techniques in the analysis of glyphosate and aminomethyl-phosphonic acid by chromatography

Arkan

Molnár-Perl

2015

Microchemical Journal

Self Cite

View full text Add to dashboard Cite

“…Overall, it is clear that phenols can differ widely in their response by the method presented here. There could be several reasons that eight of the phenols (8)(9)(10)(11)(12)(13)(14)(15) gave little or no response by MALDI-TOF-MS after derivatization with SBA, such as incomplete derivatization, instability of the derivatives in the MALDI step, and variation in the efficiency of desorption. It is interesting that all these compounds have relatively low pK a values (below 9).…”

Section: Evaporative Derivatization Of a Mixture Of Phenolsmentioning

confidence: 99%

“…Mass spectrometry is used commonly to detect phenols in both of these roles, usually as part of a gas chromatography (GC)/MS [9][10][11][12] or LC/MS [13][14][15][16]…”

mentioning

confidence: 99%

Evaporative derivatization of phenols with 2-sulfobenzoic anhydride for detection by matrix-assisted laser desorption/ionization mass spectrometry

Yao

Wang

Giese

2014

Rapid Commun. Mass Spectrom.

View full text Add to dashboard Cite

RATIONALE Phenols are an important class of analytes, for example as bioactive environmental contaminants. Towards a goal of improving their detection by MALDI-TOF-MS or MALDI-TOF/TOF-MS, we studied their derivatization with 2-sulfobenzoic anhydride (SBA). We chose SBA for this purpose since it is commercially available, inexpensive, and forms an anionic derivative. METHODS In selected conditions developed here for phenols, a reaction mixture of one or more of such compounds in acetonitrile containing SBA and 4-dimethylaminopyridine (DMAP) is evaporated to a solid, heated at 60°C for 1 h, redissolved in 50% acetonitrile containing matrix, spotted onto a MALDI target, and subjected to negative ion MALDI-TOF/TOF-MS. RESULTS While conventional (solution-phase) reaction of 4-phenylphenol (model analyte) with SBA and DMAP only gave a 47% yield of SBA-tagged 4-phenylphenol, evaporative derivatization as above gave a 96% yield, and 25 pmol (4.3 ng) of 4-phenylphenol could be detected in this way by MALDI-TOF/TOF-MS at S/N = 260, whereas even 1 nmol of the nonderivatized phenol was not detected in the absence of derivatization. A wide range of responses was observed when a mixture of 15 phenols was derivatized, with the higher responses coming from phenols with a pKa value above 9. Without derivatization, phenols with pKa values below 5 were the most readily detected. CONCLUSION Evaporative derivatization with SBA (a convenient reagent) can improve the detection of phenols with relatively high pKa values (above 9) by negative ion MALDI-TOF-MS, and accomplish this in the absence of post-derivatization reaction cleanup.

show abstract

Analysis of phenolic compounds in the dissolved and suspended phases of Lake Balaton water by gas chromatography-tandem mass spectrometry

Faludi

Balogh

Serfözö

et al. 2015

Environ Sci Pollut Res

Self Cite

View full text Add to dashboard Cite

Systematic derivatization, mass fragmentation and acquisition studies in the analysis of chlorophenols, as their silyl derivatives by gas chromatography–mass spectrometry

Cited by 18 publications

References 54 publications

The role of derivatization techniques in the analysis of glyphosate and aminomethyl-phosphonic acid by chromatography

The role of derivatization techniques in the analysis of glyphosate and aminomethyl-phosphonic acid by chromatography

Evaporative derivatization of phenols with 2-sulfobenzoic anhydride for detection by matrix-assisted laser desorption/ionization mass spectrometry

Analysis of phenolic compounds in the dissolved and suspended phases of Lake Balaton water by gas chromatography-tandem mass spectrometry

Contact Info

Product

Resources

About