2018
DOI: 10.1016/j.taap.2018.03.029
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Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish

Abstract: Superfund sites often consist of complex mixtures of polycyclic aromatic hydrocarbons (PAHs). It is widely recognized that PAHs pose risks to human and environmental health, but the risks posed by exposure to PAH mixtures are unclear. We constructed an environmentally relevant PAH mixture with the top 10 most prevalent PAHs (SM10) from a Superfund site derived from environmental passive sampling data. Using the zebrafish model, we measured body burden at 48 hours post fertilization (hpf) and evaluated the deve… Show more

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Cited by 75 publications
(54 citation statements)
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“…The PAHs include benzo(a)pyrene and other proven human carcinogens. Some PAHs are considered neurotoxic from epidemiological and clinical associations of impaired brain development (Peterson et al 2015;Finch 2018) from rodent models exposed during gestation to benzo(a)pyrene (McCallister et al 2008(McCallister et al , 2016Sheng et al 2010;Geier et al 2018;Slotkin et al 2019).…”
Section: Smoke and Cooking: Detoxification By Ahr-cyp And N-acetyltramentioning
confidence: 99%
“…The PAHs include benzo(a)pyrene and other proven human carcinogens. Some PAHs are considered neurotoxic from epidemiological and clinical associations of impaired brain development (Peterson et al 2015;Finch 2018) from rodent models exposed during gestation to benzo(a)pyrene (McCallister et al 2008(McCallister et al , 2016Sheng et al 2010;Geier et al 2018;Slotkin et al 2019).…”
Section: Smoke and Cooking: Detoxification By Ahr-cyp And N-acetyltramentioning
confidence: 99%
“…To derive internal exposure based on the external concentration of the compounds, for example based on physicochemical properties, has been shown to be very challenging 1719 . Measuring this essential internal exposure is also a challenge due to the small size of zebrafish larvae and the subsequently required very sensitive quantification methods.…”
Section: Introductionmentioning
confidence: 99%
“…There are several approaches for studying chemical mixtures, including the ‘sufficiently similar’ mixture approach proposed by the U.S. Environmental Protection Agency [54]. In an attempt to balance practicality and limited scope issues present with other mixture assessment methodologies, like whole mixture and component-based approaches [55], a sufficiently similar mixture is where proportions between chemical components match the real-world mixture [54]. Such methodologies could be applied moving forward with the common chemicals reported in this study.…”
Section: Discussionmentioning
confidence: 99%