Weak gravitational lensing of the cosmic microwave background (CMB) is an important cosmological tool that allows us to learn about the structure, composition and evolution of the Universe. Upcoming CMB experiments, such as the Simons Observatory (SO), will provide high-resolution and low-noise CMB measurements. We consider the impact of instrumental systematics on the corresponding high-precision lensing reconstruction power spectrum measurements. We simulate CMB temperature and polarization maps for an SO-like instrument and potential scanning strategy, and explore systematics relating to beam asymmetries and offsets, boresight pointing, polarization angle, gain drifts, gain calibration and electric crosstalk. Our analysis shows that the majority of the biases induced by the systematics we modeled are below a detection level of ∼ 0.6σ. We discuss potential mitigation techniques to further reduce the impact of the more significant systematics, and pave the way for future lensing-related systematics analyses.