Systematic evaluation of cancer risk associated with rs2292832 in miR-149 and rs895819 in miR-27a: a comprehensive and updated meta-analysis

Abstract

The aim of this study is to provide a precise quantification for the association between miR-149 T > C (rs2292832) and miR-27a A > G (rs895819) and the risk of cancer. We conducted a systematic literature review and evaluated the quality of included studies based on Newcastle-Ottawa Scale (NOS). Pooled odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were calculated to assess the strengths of the associations. We identified 40 studies for pooled analyses. Overall, the results demonstrated that the rs2292832 polymorphism was subtly decrease the risk of breast cancer (CT + CC vs TT: OR = 0.83, 95% CI: 0.70–0.98, P = 0.03; CC vs CT + TT: OR = 0.80, 95% CI: 0.68–0.93, P = 0.00), and the rs895819 polymorphism wasassociated with significantly increased cancer risk in the Asian population (AG + GG vs AA: OR = 1.24, 95% CI: 1.03–1.50, P = 0.02) and in colorectal cancer subgroup (GG vs AA: OR = 1.45, 95% CI: 1.10–1.92, P = 0.00; AG + GG vs AA: OR = 1.35, 95% CI: 1.15–1.58, P = 0.00; GG vs AG + AA: OR = 1.36, 95% CI: 1.04–1.77, P = 0.02). In addition, a subtly decreased risk was observed in the Caucasian population and in breast cancer subgroup. In conclusion, the rs2292832 polymorphism was significantly associated with increased breast cancer risk, and the rs895819 polymorphism contributes to the susceptibility of colorectal and breast cancer.

Association of two microRNA polymorphisms miR-27 rs895819 and miR-423 rs6505162 with the risk of cancer

“…In our meta-analysis, the rs895819 polymorphism was found to be associated with an increased risk of colorectal cancer in allele contrast model, homozygote model and recessive model. In addition, three latest publications reported similar results [ 50 – 52 ], which will make our conclusions more credible. Moreover, when analysis was stratified by ethnicity, a decreased cancer risk could be detected among Caucasians, indicating that the distinction in genetic backgrounds among different ethnic groups might have an impact on cancer susceptibility, which was in accordance with the results of five previously published studies [ 52 – 56 ] and further demonstrated the reliability of our results.…”

Distinct effects of rs895819 on risk of different cancers: an update meta-analysis

“…Fifty-eight abstracts were retrieved after the search “miR-27a”, “polymorphism” and “cancer”, and 27 articles were identified as eligible studies. Among the 58, 10 articles were pooled analysis, commentary [ 32 – 41 ] and 3 articles were review papers [ 28 , 29 , 42 ], and 3 reports were cancer biology experimental studies [ 43 – 45 ]. Ten studies were excluded because they reported non-cancer disease [ 46 – 55 ].…”

“…Based on 17 case-control studies with 7,813 cases and 9,602 controls, our previous meta-analysis did not suggest any association between rs895819 and cancer susceptibility, while rs895819 was associated with a reduced cancer risk in heterozygous, dominant or additive model in Caucasians but not in Asians [ 33 ]. By pooling 19 studies (17 articles) involving 7,800 cases and 9,060 controls, a recent study by Feng et al, failed to find any associations between rs895819 polymorphism and cancer risk, while statistically significantly reduced cancer risks were found among Asians for dominant contrast and a subtly decreased risk was observed in the Caucasian population for heterozygous or additive contrast [ 29 ]. In the present study, by including 34 studies with almost twice number of subjects, we found that rs895819 was associated with increased cancer risk in recessive model for all population and Asians, but not Caucasians, suggesting a possible ethnic difference in the genetic and the environmental factors.…”

“…Meta-analysis studies revealed that rs895819 was a functional SNP and may have some relation to colorectal cancer susceptibility, especially in Asians [ 28 ]. Generally, the current available data were inconsistent about the effects of rs895819 on carcinogenesis in different cancers [ 28 , 29 ], this discrepancy maybe partially attributed to the heterogeneity of the cancer subtype, small sample size, and ethnicity of the study population. Therefore, it is necessary to conduct a comprehensive review and meta-analysis of published data from all eligible studies on the association of rs895819 with cancer risk.…”

MicroRNA and Human Bone Health

“…MiR‐149 was downregulated in an in vitro osteoarthritis model upon inflammatory stimulation . The SNP rs2292832 in miR‐149 was shown to associate with breast cancer and ischemic stroke; however, its association with BMD in human has not been reported in literature so far.…”