Systematic evaluation of environmental and behavioural factors associated with all-cause mortality in the United States National Health and Nutrition Examination Survey

Patel, Chirag; Rehkopf, David H.; Leppert, John T.; Bortz, Walter M.; Cullen, Mark R.; Chertow, Glenn M.; Ioannidis, John P. A.

doi:10.1093/ije/dyt208

Cited by 115 publications

(99 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a separate analysis of the same NHANES 1999-2000 dataset, Patel et al (2013) found an association of Cd exposure and shortening of leucocyte telomeres, similar to the report of Zota et al (2015). In addition to Cd exposure, leukocyte telomere lengths showed an inverse association with serum CRP levels, physical activity, and trunk fat (Patel et al 2016).…”

Section: Cadmium -Mechanisms Of Toxicitysupporting

confidence: 65%

“…Chronic, low-level Cd exposure in Sweden has been linked to an increased risk of heart failure (Borne et al 2015), while chronic, low-level Cd exposure in the U.S. been linked to death from CVD, heart disease, and coronary heart disease (Tellez-Plaza et al 2012) along with increased death from all causes (Hyder et al 2013;Patel et al 2013), cancer (Adams et al 2012;Lin et al 2014), and Alzheimer's disease (Min and Min 2016).…”

Section: Resultsmentioning

confidence: 99%

“…In women, mean (range) of blood Cd levels were 0.27 (0.03-4.83) µg/L. U.S. , relatively low exposures, Patel et al (2013) Median 2.5-5.8-year follow-up of n22076 in NHANES 1999NHANES -2000NHANES , 2001NHANES -02, 2003 A 1-SD change in logged b urinary Cd levels was associated with mortality (HR 1.6, 95% CI 1.3-2.0). A 1-SD change in logged blood Cd levels was associated with mortality (HR 1.4, 95% CI 1.2-1.6).…”

Section: Cadmium -Mechanisms Of Toxicitymentioning

confidence: 93%

“…In a follow-up of the U.S. NHANES 1999-2004 participants (median 5.8, 2.8 follow-up yrs), Patel et al (2013) found a 1-SD change in logged exposure levels was associated with death from all causes (HR 1.6, 95% CI 1.3, 2.0 for urinary Cd, and HR 1.4, 95% CI 1.2, 1.6 for blood Cd). Other factors found to be associated with death along with Cd exposure are physical inactivity, smoking, and low serum lycopene (most likely reflect low-level dietary intake of vegetable antioxidants).…”

Section: Cadmium Exposure and Mortalitymentioning

confidence: 98%

“…Persistence of Cd in the environment, coupled with its high soil-to-plant transfer rates, requires long-term management of Cd in the environment (soil, air and water), and in agriculture, where consideration should be given to leafy salad vegetables, such as spinach and lettuce, which are known to be hyper-accumulators of Cd. These plants should be strictly grown on soils with low Cd levels, given that diet rich in plant and vegetables provides a rich source of exogenous antioxidants whose protective effects against Cd toxicity have indeed been observed along with overall mortality risk reduction (Patel et al 2013;Colancino et al 2014).…”

Section: Minimization Of Food-chain Transfermentioning

confidence: 99%

See 4 more Smart Citations

Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm

Satarug

Vesey

Gobé

2017

Tohoku J. Exp. Med.

104

View full text Add to dashboard Cite

Section: Cadmium -Mechanisms Of Toxicitysupporting

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Section: Cadmium -Mechanisms Of Toxicitymentioning

confidence: 93%

Section: Cadmium Exposure and Mortalitymentioning

confidence: 98%

Section: Minimization Of Food-chain Transfermentioning

confidence: 99%

See 3 more Smart Citations

Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm

Satarug

Vesey

Gobé

2017

Tohoku J. Exp. Med.

104

View full text Add to dashboard Cite

Studying the Elusive Environment in Large Scale

Patel

Ioannidis

2014

JAMA

109

View full text Add to dashboard Cite

Identification of Modifiable Social and Behavioral Factors Associated With Childhood Cognitive Performance

et al. 2020

View full text Add to dashboard Cite

social environments are likely associated with a large portion of racial disparities in childhood cognitive performance. Identification of the specific exposures associated with cognitive development is needed to inform prevention efforts.OBJECTIVE To identify modifiable factors associated with childhood cognitive performance. DESIGN, SETTING, AND PARTICIPANTSThis longitudinal pregnancy cohort study included 1503 mother-child dyads who were enrolled in the University of Tennessee Health Science Center-Conditions Affecting Neurodevelopment and Learning in Early Life study between December 1, 2006, and July 31, 2011, and assessed annually until the children were aged 4 to 6 years. The analytic sample comprised 1055 mother-child dyads. A total of 155 prenatal, perinatal, and postnatal exposures were included to evaluate environment-wide associations. Participants comprised a community-based sample of pregnant women who were recruited between 16 weeks and 28 weeks of gestation from 4 hospitals in Shelby County, Tennessee. Women with high-risk pregnancies were excluded. Data were analyzed from June 1, 2018, to April 15, 2019. EXPOSURES Individual and neighborhood socioeconomic position, family structure, maternal mental health, nutrition, delivery complications, birth outcomes, and parenting behaviors. MAIN OUTCOMES AND MEASURES Child's full-scale IQ measured by the Stanford-Binet Intelligence Scales, Fifth Edition, at age 4 to 6 years. RESULTSOf 1055 children included in the analytic sample, 532 (50.4%) were female. Among mothers, the mean (SD) age was 26.0 (5.6) years; 676 mothers (64.1%) were Black, and 623 mothers (59.0%) had an educational level of high school or less. Twenty-four factors were retained in the least absolute shrinkage and selection operator regression analysis and full models adjusted for potential confounding. Associations were noted between child cognitive performance and parental education and breastfeeding; for each increase of 1.0 SD in exposure, positive associations were found with cognitive growth fostering from observed parent-child interactions (β = 1.12; 95% CI, 0.24-2.00) and maternal reading ability (β = 1.42; 95% CI, 0.16-2.68), and negative associations were found with parenting stress (β = −1.04; 95% CI, −1.86 to −0.21). A moderate increase in these beneficial exposures was associated with a notable improvement in estimated cognitive test scores using marginal means (0.5% of an SD). Black children experienced fewer beneficial cognitive performance exposures; in a model including all 24 exposures and covariates, no racial disparity was observed in cognitive performance (95% CIs for race included the null). CONCLUSIONS AND RELEVANCEThe prospective analysis identified multiple beneficial and modifiable cognitive performance exposures that were associated with mean differences in cognitive performance by race. The findings from this observational study may help guide experimental studies focused on reducing racial disparities in childhood cognitive performance.

show abstract

Systematic evaluation of environmental and behavioural factors associated with all-cause mortality in the United States National Health and Nutrition Examination Survey

Cited by 115 publications

References 46 publications

Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm

Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm

Studying the Elusive Environment in Large Scale

Identification of Modifiable Social and Behavioral Factors Associated With Childhood Cognitive Performance

Contact Info

Product

Resources

About