2019
DOI: 10.1016/j.ejps.2019.05.015
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Systematic evaluation of the impact of solid-state polymorphism on the bioavailability of thalidomide

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Cited by 7 publications
(5 citation statements)
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“…Then the test was carried out with SI and q values using a sink condition with a 500 mL surfactant medium. (Oliveira et al, 2019).…”
Section: Bioavailabilitymentioning
confidence: 99%
See 1 more Smart Citation
“…Then the test was carried out with SI and q values using a sink condition with a 500 mL surfactant medium. (Oliveira et al, 2019).…”
Section: Bioavailabilitymentioning
confidence: 99%
“…However, the speed and high extension of the dissolution test on α-TLD illustrates good pharmacokinetics and bioavailability. It is recommended that the pharmaceutical industry use polymorph α-TLD as an active ingredient (Oliveira et al, 2019).…”
Section: Bioavailabilitymentioning
confidence: 99%
“…Log P characterize the hydrophilic or lipophilic character of a molecule (Chmiel et al, 2019) and calculated by the logarithm of the partition coefficient between octanol and water. It is used to evaluate the bioavailability of a molecule: Log P< 0, the molecule is said hydrophilic; Log P >5, the molecule is lipophilic; A good balance is needed between the hydrophilic and hydrophobic character for an optimal biological activity 0<Log P<5 (de Oliveira et al, 2019). A molecule with an optimal biological activity is sufficiently hydrophilic to be soluble in aqueous media (blood, cytoplasm...) and in the same time it must have a hydrophobic character to pass through the membranes (Pieńko et al, 2016).…”
Section: Physicochemical Propertiesmentioning
confidence: 99%
“…As the physicochemical properties of a drug can influence its performance in formulation processing and later its bioavailability, the fundamental concept of its crystalline state should be understood before formulation design (Datta & Grant, 2004). For instance, numerous drug entities have been evaluated on their polymorph transformation in recent years (Zhang & Chen, 2017;Zanolla et al, 2018;Paczkowska et al, 2018;de Oliveira et al, 2019;Salazar-Rojas et al, 2020). On the other hand, amorphous content has been proved to increase the solubility and dissolution rate in amorphous solid dispersion (ASD) (Mendes et al, 2019;Kwon et al, 2019;Angi et al, 2019;Pinto et al, 2020;Teoh et al, 2020).…”
Section: Introductionmentioning
confidence: 99%