Systematic fabrication of chitosan nanoparticle by gamma irradiation

Deoxycholate‐chitosan nanospheres fabricated by γ‐irradiation and chemical modification: Nanoscale synthesis and controlled studies

“…It was suspected that the irradiated dose may not be important influence on the amount of chemical conjugation. Although higher γ‐ray doses resulted in shorter chitosan chain lengths (as reported in our previous work35), the amount of the amino groups, which are the conjugating sites, was suspected to be unchanged for pre‐irradiation doses in the given range of 5–100 kGy. In other words, γ‐ray irradiation did not affect the amino groups (at C‐2) of aqueous Cs‐colloid 35.…”

“…The starting irradiated chitosan (Cs‐colloid and Cs‐flake) for chemical conjugation was in colloidal form, which was prepared according to Pasanphan et al35 For the heterogeneous system, deoxycholic acid (DA 0.7851 g, 1 mol equivalent to chitosan) in methanolic solution (50 mL) was added to colloidal chitosan (0.1631 g, 1 mol). EDC, 0.3834 g, 1 mol equivalent to chitosan, was then added to the mixture of chitosan and DA.…”

“…To our knowledge, although many chitosan derivatives in self‐assembly forms have been reported, the development of a systematic protocol for reducing and controlling the particle size of hydrophobically modified chitosan micelles using γ‐irradiation has not yet been studied. Recently, our group proposed a systematic protocol for preparing and reducing the particle size of self‐aggregating non‐modified chitosan nanoparticles in an aqueous solution, using a γ‐irradiation process 35. Radiolytic methodology using γ irradiation has been extensively used for polymer modification36–41 due to the simplicity of the process, which involves single‐step preparation without purification.…”

Effects of irradiated Ergosan on the growth performance and mucus biological components of rainbow trout Oncorhynchus mykiss

“…Gamma-irradiation is a physically eff ective, simple, reproductive, and environmentally friendly technique (Byun et al, 2008;Pasanphan et al, 2010). Gamma irradiation has been extensively used to generate nanoscale metals and nanocomposites at room temperature and normal pressure (Karim et al, 2007).…”

Influence of Poly (Ethylene Glycol) on the Characteristics of γ Radiation-Crosslinked Poly (Vinyl Pyrrolidone)-Low Molecular Weight Chitosan Network Hydrogels

“…According to Park et al (2012), PEG reduces gel fraction of PVA hydrogel because PEG remains between the PVA chain and avoiding FIGURE 2. The radiolysis of water molecule, the formation of PVP-radicals by reactive ۰OH radicals and the recombination of PVP-radicals to form covalent crosslinked network (Can 2005;Pasanphan et al 2010) the progressive crosslinking reaction of PVA chain. The incorporation of hydrophilic polymer whose hydrophilicity is different from the initial hydrogel system interrupt the crosslinking reaction and hence reduces the crosslinking density (Berger et al 2004).…”