Systematic Identification of circRNAs in Alzheimer’s Disease

Cochran, Kyle R.; Veeraraghavan, Kirtana; Kundu, Gautam; Mazan-Mamczarz, Krystyna; Coletta, Christopher; Thambisetty, Madhav; Gorospe, Myriam; De, Supriyo

doi:10.3390/genes12081258

Cited by 10 publications

(11 citation statements)

References 57 publications

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“…Some studies reported that circRNAs could play an important role in AD [ 8 , 15 ], even as possible biomarkers [ 8 ]. However, to our knowledge, only one paper was published investigating a profile of plasmatic circRNAs in AD [ 16 ], while no studies are available on subjects with MCI. The study reported that 15 circRNAs were significantly higher in participants with AD compared to HCs from two different populations (GSE161199 and PRJNA574438).…”

Section: Discussionmentioning

confidence: 99%

A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer’s Disease and Mild Cognitive Impairment from Healthy Controls

Manzini

Rivabene

Crestini

et al. 2022

IJMS

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The most frequently used biomarkers to support the diagnosis of Alzheimer’s Disease (AD) are Aβ42, total-Tau, and phospho-tau protein levels in CSF. Moreover, magnetic resonance imaging is used to assess hippocampal atrophy, 18F-FDG PET to identify abnormal brain metabolism, and PET imaging for amyloid deposition. These tests are rather complex and invasive and not easily applicable to clinical practice. Circulating non-coding RNAs, which are inherently stable and easy to manage, have been reported as promising biomarkers for central nervous system conditions. Recently, circular RNAs (circRNAs) as a novel class of ncRNAs have gained attention. We carried out a pilot study on five participants with AD and five healthy controls (HC) investigating circRNAs by Arraystar Human Circular RNA Microarray V2.0. Among them, 26 circRNAs were differentially expressed (FC ≥ 1.5, p < 0.05) in participants with AD compared to HC. From a top 10 of differentially expressed circRNAs, a validation study was carried out on four up-regulated (hsa_circRNA_050263, hsa_circRNA_403959, hsa_circRNA_003022, hsa_circRNA_100837) and two down-regulated (hsa_circRNA_102049, hsa_circRNA_102619) circRNAs in a larger population. Moreover, five subjects with mild cognitive impairment (MCI) were investigated. The analysis confirmed the upregulation of hsa_circRNA_050263, hsa_circRNA_403959, and hsa_circRNA_003022 both in subjects with AD and in MCI compared to HCs. We also investigated all microRNAs potentially interacting with the studied circRNAs. The GO enrichment analysis shows they are involved in the development of the nervous system, and in the cellular response to nerve growth factor stimuli, protein phosphorylation, apoptotic processes, and inflammation pathways, all of which are processes related to the pathology of AD.

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Section: Discussionmentioning

confidence: 99%

A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer’s Disease and Mild Cognitive Impairment from Healthy Controls

Manzini

Rivabene

Crestini

et al. 2022

IJMS

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“…It is helpful for the diagnosis and treatment of AD to understand how related molecules participate in these processes. Due to the rapid development of high-throughput RNA-seq technologies, the dynamic expression patterns and functions of circRNAs in AD have been characterized recently in a large number of studies ( Dube et al, 2019 ; Cervera-Carles et al, 2020 ; Cochran et al, 2021 ).…”

Section: Involvement Of Circrnas In Cognitive-related Diseasesmentioning

confidence: 99%

Circular RNAs: New players involved in the regulation of cognition and cognitive diseases

Liu²,

Chang³

et al. 2023

Front. Neurosci.

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Circular RNAs (circRNAs), a type of covalently closed endogenous single-stranded RNA, have been regarded as the byproducts of the aberrant splicing of genes without any biological functions. Recently, with the development of high-throughput sequencing and bioinformatics, thousands of circRNAs and their differential biological functions have been identified. Except for the great advances in identifying circRNA roles in tumor progression, diagnosis, and treatment, accumulated evidence shows that circRNAs are enriched in the brain, especially in the synapse, and dynamically change with the development or aging of organisms. Because of the specific roles of synapses in higher-order cognitive functions, circRNAs may not only participate in cognitive functions in normal physiological conditions but also lead to cognition-related diseases after abnormal regulation of their expression or location. Thus, in this review, we summarized the progress of studies looking at the role of circRNA in cognitive function, as well as their involvement in the occurrence, development, prognosis, and treatment of cognitive-related diseases, including autism, depression, and Alzheimer’s diseases.

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“…This autophagic protein is important for clearing amyloid peptides and is less abundant in the AD brain. Consequently, ciRS-7 may participate in AD pathogenesis [ 135 , 137 , 138 ].…”

Section: Circular Rnasmentioning

confidence: 99%

Context-Dependent Regulation of Gene Expression by Non-Canonical Small RNAs

Plawgo

Raczyńska

2022

ncRNA

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In recent functional genomics studies, a large number of non-coding RNAs have been identified. It has become increasingly apparent that noncoding RNAs are crucial players in a wide range of cellular and physiological functions. They have been shown to modulate gene expression on different levels, including transcription, post-transcriptional processing, and translation. This review aims to highlight the diverse mechanisms of the regulation of gene expression by small noncoding RNAs in different conditions and different types of human cells. For this purpose, various cellular functions of microRNAs (miRNAs), circular RNAs (circRNAs), snoRNA-derived small RNAs (sdRNAs) and tRNA-derived fragments (tRFs) will be exemplified, with particular emphasis on the diversity of their occurrence and on the effects on gene expression in different stress conditions and diseased cell types. The synthesis and effect on gene expression of these noncoding RNAs varies in different cell types and may depend on environmental conditions such as different stresses. Moreover, noncoding RNAs play important roles in many diseases, including cancer, neurodegenerative disorders, and viral infections.

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Systematic Identification of circRNAs in Alzheimer’s Disease

Cited by 10 publications

References 57 publications

A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer’s Disease and Mild Cognitive Impairment from Healthy Controls

A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer’s Disease and Mild Cognitive Impairment from Healthy Controls

Circular RNAs: New players involved in the regulation of cognition and cognitive diseases

Context-Dependent Regulation of Gene Expression by Non-Canonical Small RNAs

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