Systematic identification of key genes and pathways in the development of invasive cervical cancer

Minichromosome Maintenance Complex (MCM) Genes Profiling and MCM2 Protein Expression in Cervical Cancer Development

“…The highest fold change was in the SCC group. The results in our study concur with others that report an upregulation of MCM2, 4 and 5 genes in cervical SCC compared to normal samples (Niu et al, 2017;. MCM2, 4, 5,6 and 7 were also found to be upregulated in cervical cancer using semi-quantitative RT-PCR technique (Das et al, 2013).…”

“…The MCM proteins are markers of cell proliferation and have been shown to be highly expressed in a variety of cancers including breast, lung, colorectal and many other types of cancers (Shetty et al, 2005;Giaginis et al, 2009;Liu et al, 2017). Though studies have reported on MCM expression in cervical cancer, very few have analysed the whole spectrum of transformation of HPV-infected cervix into pre-cancerous lesions (LSIL and HSIL) and further into invasive cancer (Das et al, 2013;Niu et al, 2017;Saritha et al, 2018). This study aimed to evaluate the MCM mRNA expressions in HPV-associated pre-cancerous and cervical cancer tissues, to better understand their role in cervical carcinogenesis.…”

The family of the interleukin‐1 receptors

“…expression was found increased in squamous cell carcinoma, 157 and IL-1R2 expression inhibition by shRNA could inhibit the proliferation of osteosarcoma cells in culture. 158 Although all these associations do not indicate a cause-effect relationship, it is in any case evident that pathological situations imply alterations of IL-1R complex members.…”

“…In respiratory diseases, hypomethylation of the IL1R2 gene was associated with disease severity in obstructive sleep apnea, whereas alveolar macrophages and circulating leukocytes of patient with acute respiratory distress syndrome showed increased expression of the IL1R2 gene and higher levels of circulating sIL‐1R2, correlating with survival . In cancer, IL1R2 expression was found increased in squamous cell carcinoma, and IL‐1R2 expression inhibition by shRNA could inhibit the proliferation of osteosarcoma cells in culture …”

Prevalence and Distribution of High-Risk Human Papillomavirus Genotypes in Invasive Carcinoma of the Uterine Cervix in Uruguay. An update on clinical outcome

“…Recently, in the era of precision medicine, increasing evidence in databases suggest the potential usefulness of deregulated genes as biomarkers able to predict both, response to treatment and survival, as well as molecular targets in CC patients (Niu, 2017). Among several examples, MVP (major vault protein), IGF-1R (insulin-like growth factor 1 receptor), and BCL2 (B cell lymphoma 2) expression in tumor tissues have been suggested as useful biomarkers for an optimal planning of therapeutic strategy (Valenciano, 2014).…”