2024
DOI: 10.1038/s41598-024-62002-5
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Systematic in-silico evaluation of fibrosis effects on re-entrant wave dynamics in atrial tissue

Michela Masè,
Alessandro Cristoforetti,
Samuele Pelloni
et al.

Abstract: Despite the key role of fibrosis in atrial fibrillation (AF), the effects of different spatial distributions and textures of fibrosis on wave propagation mechanisms in AF are not fully understood. To clarify these aspects, we performed a systematic computational study to assess fibrosis effects on the characteristics and stability of re-entrant waves in electrically-remodelled atrial tissues. A stochastic algorithm, which generated fibrotic distributions with controlled overall amount, average size, and orient… Show more

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