Systematic in Vitro Evaluation of Survivin Directed Antisense Oligodeoxynucleotides in Bladder Cancer Cells

Fuessel, Susanne; Kueppers, Bernd; Ning, Shuangli; Kotzsch, Matthias; Kraemer, Kai; Schmidt, Frank; Meye, Axel; Wirth, Manfred P.

doi:10.1097/01.ju.0000116410.13874.b8

Cited by 43 publications

(24 citation statements)

References 16 publications

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“…As survivin is known to preferentially bind to and inhibit effector caspases, such as caspase-3 and caspase-7 (Tamm et al, 1998), its reduction by ASODNs in TT cells may potentially contribute to the cell apoptosis. In addition, overt inhibitory effects on cell growth and notable induction of apoptosis by ASODNs have also been found in other tumor cell lines (Xia et al, 2002;Cao et al, 2004;Fuessel et al, 2004;. Thus, the survivin-targeted gene therapy using ASODNs may be one of potentially promising alternatives for treatment of tumors.…”

Section: Discussionmentioning

confidence: 99%

Antisurvivin oligonucleotides inhibit growth and induce apoptosis in human medullary thyroid carcinoma cells

Zhang²,

Gao³

et al. 2006

Exp Mol Med

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Section: Discussionmentioning

confidence: 99%

Antisurvivin oligonucleotides inhibit growth and induce apoptosis in human medullary thyroid carcinoma cells

Zhang²,

Gao³

et al. 2006

Exp Mol Med

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“…These strategies comprise antisense oligonucleotides, ribozymes, siRNA, and dominant-negative mutation (35)(36)(37). Promising results have already been reported for survivin targeting in bladder cancer cell lines (38)(39)(40).…”

Section: Deregulated Expression Of Apoptosis Inhibitors Have Beenmentioning

confidence: 96%

Survivin Expression as a Predictive Marker for Local Control in Patients With High-Risk T1 Bladder Cancer Treated With Transurethral Resection and Radiochemotherapy

Weiß

Römer

Capalbo

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…Promising results have already been reported for survivin targeting in bladder cancer cell lines. 32,33 …”

Section: Discussionmentioning

confidence: 99%

Quantitative analysis of survivin mRNA expression in urine and tumor tissue of bladder cancer patients and its potential relevance for disease detection and prognosis

Weikert

Christoph

Schrader

et al. 2005

Intl Journal of Cancer

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Suppression of apoptosis may favor the onset and progression of cancer. Survivin is an inhibitor of apoptosis that has been suggested as a novel diagnostic/prognostic marker of bladder cancer. In this study, survivin mRNA expression was measured by a sensitive real-time PCR assay in tumor tissue and urine from bladder cancer patients and assessed for its potential diagnostic and prognostic relevance. Specimens from 53 patients with bladder transitional cell carcinoma (TCC) were analyzed, the controls being normal urothelial tissues (n = 14) and urine from benign disease patients (n = 22) and healthy individuals (n = 14). Survivin transcripts were commonly detected in tumor tissues, but not in normal urothelium, and increasing mRNA levels correlate with progressing pathologic stage (p = 0.001) and grade categories (p < 0.004). Higher levels of expression were associated with a reduced time to recurrence in noninvasive TCCs (p = 0.027, logrank test) and a trend toward shorter disease-free survival in muscle-invasive tumors (p = 0.067). Urinary survivin analysis detects TCC with higher sensitivity (68.6%) and equal specificity (100%) when compared with cytology (31.4% and 97.1%). Our results indicate that tissue levels of survivin mRNA predict disease-free survival in noninvasive TCC and may have a role in bladder cancer progression. When analyzed by RT-PCR in urine, survivin is a highly specific biomarker for TCC detection. ' 2005 Wiley-Liss, Inc.

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Systematic in Vitro Evaluation of Survivin Directed Antisense Oligodeoxynucleotides in Bladder Cancer Cells

Abstract: The survivin directed AS-ODNs shown to inhibit effectively the proliferation of BCa cells in the current study may provide suitable adjuvant therapeutic agents for the specific local treatment of BCa.

Cited by 43 publications

References 16 publications

Antisurvivin oligonucleotides inhibit growth and induce apoptosis in human medullary thyroid carcinoma cells

Antisurvivin oligonucleotides inhibit growth and induce apoptosis in human medullary thyroid carcinoma cells

Survivin Expression as a Predictive Marker for Local Control in Patients With High-Risk T1 Bladder Cancer Treated With Transurethral Resection and Radiochemotherapy

Quantitative analysis of survivin mRNA expression in urine and tumor tissue of bladder cancer patients and its potential relevance for disease detection and prognosis

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