Systematic in vitro nanotoxicity study on anodic alumina nanotubes with engineered aspect ratio: Understanding nanotoxicity by a nanomaterial model

Wang, Ye; Kaur, Gagandeep; Zysk, Aneta; Liapis, Vasilios; Hay, Shelley; Santos, Abel; Lošić, Dušan; Evdokiou, Andreas

doi:10.1016/j.biomaterials.2014.12.008

Cited by 43 publications

(26 citation statements)

References 56 publications

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“…A similar trend was observed by comparing the toxic behavior of rod-shaped zinc oxide (ZnO) NPs versus spherical counterparts on A549 [88], although it should be noted that A549 cells are not highly phagocytic in nature. Using different types of cells, similar conclusions were made in the work of Wang et al [89], in which long anodic alumina nanotubes (AANTs-L) triggered significant alternations in cell morphology, TNF-α release, lysosomal membrane permeabilization (LMP), and ER stress leading to cell death and inflammation to a greater extent than shorter nanotubes. This study was performed on both RAW 264.7 mouse macrophage cells and MDA-MB 231-TXSA human breast cancer cells.…”

Section: General Aspects Of Dds Toxicologysupporting

confidence: 73%

Unintended effects of drug carriers: Big issues of small particles

Parhiz

Khoshnejad

Myerson

et al. 2018

Advanced Drug Delivery Reviews

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Humoral and cellular host defense mechanisms including diverse phagocytes, leukocytes, and immune cells have evolved over millions of years to protect the body from microbes and other external and internal threats. These policing forces recognize engineered sub-micron drug delivery systems (DDS) as such a threat, and react accordingly. This leads to impediment of the therapeutic action, extensively studied and discussed in the literature. Here, we focus on side effects of DDS interactions with host defenses. We argue that for nanomedicine to reach its clinical potential, the field must redouble its efforts in understanding the interaction between drug delivery systems and the host defenses, so that we can engineer safer interventions with the greatest potential for clinical success.

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Section: General Aspects Of Dds Toxicologysupporting

confidence: 73%

Unintended effects of drug carriers: Big issues of small particles

Parhiz

Khoshnejad

Myerson

et al. 2018

Advanced Drug Delivery Reviews

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“…[29][30][31][32][33][34][35][36][37][38][39] The development of optical platforms based on NAA has spread the use of this nanomaterial, typically used as a nanoporous template to grow other nanostructures such as nanowires and nanotubes 15 , towards more relevant applications such as optical sensing systems, drug delivery chips and photonic tags. [40][41][42][43][44][45][46][47][48][49][50][51] In this study, we present an innovative and rationally designed pulse anodisation approach, so called pseudo-stepwise pulse anodisation (PSPA), which enables the fabrication of nanoporous anodic alumina optical bandpass filters (NAABPFs) with advanced optical properties (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

Rational engineering of nanoporous anodic alumina optical bandpass filters

et al. 2016

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Herein, we present a rationally designed advanced nanofabrication approach aiming at producing a new type of optical bandpass filters based on nanoporous anodic alumina photonic crystals. The photonic stop band of nanoporous anodic alumina (NAA) is engineered in depth by means of a pseudo-stepwise pulse anodisation (PSPA) approach consisting in pseudostepwise asymmetric current density pulses. This nanofabrication method makes it possible to tune the transmission bands of NAA at specific wavelengths and bandwidths, which can be broadly modified across the UV-visible-NIR spectrum through the anodisation period (i.e. time between consecutive pulses). First, we establish the effect of the anodisation period as a means of tuning the position and width of the transmission bands of NAA across the UV -visible-NIR spectrum. To this end, a set of nanoporous anodic alumina bandpass filters (NAA-BPFs) are produced with different anodisation periods, ranging from 500 to 1200 s, and their optical properties (i.e. characteristic transmission bands and interferometric colours) are systematically assessed. Then, we demonstrate that the rational combination of stacked NAABPFs consisting of layers of NAA produced with different PSPA periods can be readily used to create a set of unique and highly selective optical bandpass filters with characteristic transmission bands, the position, width and number of which can be precisely engineered by this rational anodisation approach. Finally, as a proof-of-concept, we demonstrate that the superposition of stacked NAA-BPFs produced with slight modifications of the anodisation period enables the fabrication of NAA-BPFs with unprecedented broad transmission bands across the UV-visible-NIR spectrum. The results obtained from our study constitute the first comprehensive rationale towards advanced NAA-BPFs with fully controllable photonic properties. These photonic crystal structures could become a promising alternative to traditional optical bandpass filters based on glass and plastic.

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“…In vivo applications especially require materials that exhibit excellent stability in the biological environment. Some studies have demonstrated that AAO (or modified AAO) can be stable under moderate physiological conditions and presents negligible cytotoxicity [35,36,37,38,39,40]. However, for some bio-device processing purposes (e.g., sterilization or functionalization) it is desirable to have a material which can tolerate slightly stronger acid or basic environments with minimum structural damages.…”

Section: Resultsmentioning

confidence: 99%

Nanocarbon-Coated Porous Anodic Alumina for Bionic Devices

et al. 2015

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A highly-stable and biocompatible nanoporous electrode is demonstrated herein. The electrode is based on a porous anodic alumina which is conformally coated with an ultra-thin layer of diamond-like carbon. The nanocarbon coating plays an essential role for the chemical stability and biocompatibility of the electrodes; thus, the coated electrodes are ideally suited for biomedical applications. The corrosion resistance of the proposed electrodes was tested under extreme chemical conditions, such as in boiling acidic/alkali environments. The nanostructured morphology and the surface chemistry of the electrodes were maintained after wet/dry chemical corrosion tests. The non-cytotoxicity of the electrodes was tested by standard toxicity tests using mouse fibroblasts and cortical neurons. Furthermore, the cell–electrode interaction of cortical neurons with nanocarbon coated nanoporous anodic alumina was studied in vitro. Cortical neurons were found to attach and spread to the nanocarbon coated electrodes without using additional biomolecules, whilst no cell attachment was observed on the surface of the bare anodic alumina. Neurite growth appeared to be sensitive to nanotopographical features of the electrodes. The proposed electrodes show a great promise for practical applications such as retinal prostheses and bionic implants in general.

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Systematic in vitro nanotoxicity study on anodic alumina nanotubes with engineered aspect ratio: Understanding nanotoxicity by a nanomaterial model

Cited by 43 publications

References 56 publications

Unintended effects of drug carriers: Big issues of small particles

Unintended effects of drug carriers: Big issues of small particles

Rational engineering of nanoporous anodic alumina optical bandpass filters

Nanocarbon-Coated Porous Anodic Alumina for Bionic Devices

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