Systematic Infection of Chlamydia Pneumoniae

Ma, Yanlin; Sun, Jian; Che, Guanghua; Cheng, Huanji

doi:10.7754/clin.lab.2021.210908

Cited by 5 publications

(3 citation statements)

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“…Although mortality resulting from Cpn infection can reach as high as 9.8% ( 46 ), early treatment can effectively improve prognosis ( 47 ). Furthermore, the detection of Cpn DNA in atherosclerotic plaques (AS plaques), nerve tissue, and synovial tissue substantiates the link between Cpn infection and chronic diseases such as atherosclerosis, Alzheimer’s disease, and reactive arthritis ( 48 ).…”

Section: Discussionmentioning

confidence: 69%

Potential co-infection of influenza A, influenza B, respiratory syncytial virus, and Chlamydia pneumoniae: a case report with literature review

Feng,

Wen,

Xue

et al. 2024

Front. Med.

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The occurrence of a co-infection involving four distinct respiratory pathogens could be underestimated. Here, we report the case of a 72-year-old woman who presented to a community hospital with a cough productive of sputum as her main clinical manifestation. Antibody detection of common respiratory pathogens revealed potential co-infection with influenza A, influenza B, respiratory syncytial virus, and Chlamydia pneumoniae. We treated her with 75 mg oseltamivir phosphate administered orally twice daily for 5 days, 0.5 g azithromycin administered orally for 5 days, and 0.3 g acetylcysteine aerosol inhaled twice daily for 3 days. The patient showed a favorable outcome on the eighth day after early diagnosis and treatment. Since co-infection with these four pathogens is rare, we performed an extensive PubMed search of similar cases and carried out a systematic review to analyze the epidemiology, clinical manifestations, transmission route, susceptible population, and outcomes of these four different pathogens. Our report highlights the importance for general practitioners to be vigilant about the possibility of mixed infections when a patient presents with respiratory symptoms. Although these symptoms may be mild, early diagnosis and timely treatment could improve outcomes. Additionally, further research is warranted to explore the potential influence of SARS-CoV-2 infection on the co-occurrence of multiple respiratory pathogens.

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Section: Discussionmentioning

confidence: 69%

Potential co-infection of influenza A, influenza B, respiratory syncytial virus, and Chlamydia pneumoniae: a case report with literature review

Feng,

Wen,

Xue

et al. 2024

Front. Med.

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“…Chlamydia pneumoniae is a causative agent of pneumonia and bronchitis, and has also been implicated in an extensive list of chronic inflammatory diseases, which include arthritis, atherosclerosis, multiple sclerosis, Alzheimer's disease, COPD, asthma, and primary biliary cirrhosis [124,125]. Many of these diseases linked to C. pneumoniae are more common or more serious in aged individuals.…”

Section: Studies In Infectious Diseasesmentioning

confidence: 99%

Back to the Basics: Usefulness of Naturally Aged Mouse Models and Immunohistochemical and Quantitative Morphologic Methods in Studying Mechanisms of Lung Aging and Associated Diseases

et al. 2023

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Aging-related molecular and cellular alterations in the lung contribute to an increased susceptibility of the elderly to devastating diseases. Although the study of the aging process in the lung may benefit from the use of genetically modified mouse models and omics techniques, these approaches are still not available to most researchers and produce complex results. In this article, we review works that used naturally aged mouse models, together with immunohistochemistry (IHC) and quantitative morphologic (QM) methods in the study of the mechanisms of the aging process in the lung and its most commonly associated disorders: cancer, chronic obstructive pulmonary disease (COPD), and infectious diseases. The advantage of using naturally aged mice is that they present characteristics similar to those observed in human aging. The advantage of using IHC and QM methods lies in their simplicity, economic accessibility, and easy interpretation, in addition to the fact that they provide extremely important information. The study of the aging process in the lung and its associated diseases could allow the design of appropriate therapeutic strategies, which is extremely important considering that life expectancy and the number of elderly people continue to increase considerably worldwide.

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“…It can, however, also affect the immune system and continue to exist as a persistent infection inside cells, including white blood cells. People over 60 are most susceptible to this [97,98].…”

Section: Bacteria 221 Chlamydophila Pneumoniae (Clamydia)mentioning

confidence: 99%

Neuroinflammation in Alzheimer’s Disease: A Potential Role of Nose-Picking in Pathogen Entry via the Olfactory System?

Zhou,

Kumar,

Bhuyan

et al. 2023

Biomolecules

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Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline and memory impairment. Many possible factors might contribute to the development of AD, including amyloid peptide and tau deposition, but more recent evidence suggests that neuroinflammation may also play an—at least partial—role in its pathogenesis. In recent years, emerging research has explored the possible involvement of external, invading pathogens in starting or accelerating the neuroinflammatory processes in AD. In this narrative review, we advance the hypothesis that neuroinflammation in AD might be partially caused by viral, bacterial, and fungal pathogens entering the brain through the nose and the olfactory system. The olfactory system represents a plausible route for pathogen entry, given its direct anatomical connection to the brain and its involvement in the early stages of AD. We discuss the potential mechanisms through which pathogens may exploit the olfactory pathway to initiate neuroinflammation, one of them being accidental exposure of the olfactory mucosa to hands contaminated with soil and feces when picking one’s nose.

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Systematic Infection of Chlamydia Pneumoniae

Cited by 5 publications

References 0 publications

Potential co-infection of influenza A, influenza B, respiratory syncytial virus, and Chlamydia pneumoniae: a case report with literature review

Potential co-infection of influenza A, influenza B, respiratory syncytial virus, and Chlamydia pneumoniae: a case report with literature review

Back to the Basics: Usefulness of Naturally Aged Mouse Models and Immunohistochemical and Quantitative Morphologic Methods in Studying Mechanisms of Lung Aging and Associated Diseases

Neuroinflammation in Alzheimer’s Disease: A Potential Role of Nose-Picking in Pathogen Entry via the Olfactory System?

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