Systematic interaction of plasma albumin with the efficacy of chemotherapeutic drugs

Yu, Liuchunyang; Hua, Zhenglai; Luo, Xinyi; Zhao, Ting; Liu, Yuanyan

doi:10.1016/j.bbcan.2021.188655

Cited by 22 publications

(6 citation statements)

References 159 publications

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“…[2][3][4] Meanwhile, HSA has been the focus of attention in the pharmaceutical industry because of its large number of drug binding sites. 5 Therefore, rapid purification and separation of HSA from complex samples is a prerequisite for subsequent analysis or function studies of HSA.…”

Section: Introductionmentioning

confidence: 99%

Multi-stimuli responsive molecularly imprinted nanoparticles with tailorable affinity for modulated specific recognition of human serum albumin

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Multi-stimuli responsive molecularly imprinted nanoparticles with tailorable affinity for modulated specific recognition of human serum albumin

et al. 2022

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“…The underlying mechanism is that FcRn-mediated transcellular recycling mechanism protects albumin-binding drugs from degradation by serum and tissue proteases. The protective role of FcRn extends the circulatory half-life of albumin-binding drugs, and improve their uptake and utilization by target tissues (Yu et al, 2022). New treatment perspectives have been suggested based on the mechanism.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-related genes predict prognosis and response to immune checkpoint inhibitors in bladder cancer

et al. 2022

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Neutrophils play a key role in the occurrence and development of cancer. However, the relationship between neutrophils and cancer prognosis remains unclear due to their great plasticity and diversity. To explore the effects of neutrophils on the clinical outcome of bladder cancer, we acquired and analyzed gene expression data and clinical information of bladder cancer patients from IMvigor210 cohort and The Cancer Genome Atlas dataset (TCGA) database. We established a neutrophil-based prognostic model incorporating five neutrophil-related genes (EMR3, VNN1, FCGRT, HIST1H2BC, and MX1) and the predictive value of the model was validated in both an internal and an external validation cohort. Multivariate Cox regression analysis further proved that the model remained an independent prognostic factor for overall survival and a nomogram was constructed for clinical practice. Additionally, FCGRT was identified as the key neutrophil-related gene linked to an adverse prognosis of bladder cancer. Up-regulation of FCGRT indicated activated cancer metabolism, immunosuppressive tumor environment, and dysregulated functional status of immune cells. FCGRT overexpression was also correlated with decreased expression of PD-L1 and low levels of tumor mutation burden (TMB). FCGRT predicted a poor response to immunotherapy and had a close correlation with chemotherapy sensitivity. Taken together, a novel prognostic model was developed based on the expression level of neutrophil-related genes. FCGRT served as a promising candidate biomarker for anti-cancer drug response, which may contribute to individualized prognostic prediction and may contribute to clinical decision-making.

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“…Meanwhile, albumin can also bind to fatty acids, which can affect tumor proliferation and metabolism. 16 It was reported that albumin, which reflects nutritional status, was also closely related to the prognosis of many kinds of solid malignancies, including NSCLC, 17–19 Laryngeal Carcinoma, 20 prostate cancer, 15 upper tract urothelial Carcinoma, 21 gastric cancer. 22 …”

Section: Introductionmentioning

confidence: 99%

Pretreatment Fibrinogen-Albumin Ratio (FAR) Associated with Treatment Response and Survival in Advanced Non-Small Cell Lung Cancer Patients Treated with First-Line Anti-PD-1 Therapy Plus Platinum-Based Combination Chemotherapy

Yuan¹,

Huang²,

Wang³

et al. 2022

CMAR

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Purpose PD-1 inhibitors have been routinely used to treat advanced non-small cell lung cancer (NSCLC) and have significantly improved clinical outcomes. In this study, we aimed to explore the influence of pretreatment fibrinogen-albumin ratio (FAR) on treatment response and survival in advanced NSCLC patients treated with first-line anti-PD-1 therapy plus platinum-based combination chemotherapy. Patients and Methods A total of 91 patients with advanced NSCLC were included in the study. All patients received at least two cycles of systemic first-line anti-PD-1 therapy plus platinum-based combination chemotherapy. Receiver operating characteristics analysis was performed to determine the optimal cutoff values of FAR. Univariate and multivariate analyses were used to identify independent prognostic factors, and the Kaplan–Meier method was used to estimate survival curves. Results Multivariate logistic regression analysis showed that N stage (N2-3) and high FAR (≥0.175, optimal cutoff value) were independent predictors for objective response rate (P = 0.0002, P = 0.0005, respectively). Multivariate Cox regression analysis of progression-free survival and overall survival showed that high FAR (≥0.145) was independent prognostic factors (P = 0.0061, P = 0.0024, respectively). Progression-free survival and overall survival were significantly shorter in the high FAR (≥0.145) group than those in the low FAR (<0.145) group (P = 0.0024, P = 0.0024, respectively). Conclusion Pretreatment FAR was an independent predictor for treatment response and independent prognostic factors in advanced NSCLC patients treated with first-line anti-PD-1 therapy plus platinum-based combination chemotherapy.

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Systematic interaction of plasma albumin with the efficacy of chemotherapeutic drugs

Cited by 22 publications

References 159 publications

Multi-stimuli responsive molecularly imprinted nanoparticles with tailorable affinity for modulated specific recognition of human serum albumin

Multi-stimuli responsive molecularly imprinted nanoparticles with tailorable affinity for modulated specific recognition of human serum albumin

Neutrophil-related genes predict prognosis and response to immune checkpoint inhibitors in bladder cancer

Pretreatment Fibrinogen-Albumin Ratio (FAR) Associated with Treatment Response and Survival in Advanced Non-Small Cell Lung Cancer Patients Treated with First-Line Anti-PD-1 Therapy Plus Platinum-Based Combination Chemotherapy

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