In this study we investigate the stability limits of Micromegas detectors upon irradiation
with alpha particles. The results are obtained with meshes with different optical transparency and
geometry of wires. The measurements are performed in Ar- and Ne- based mixtures with different
CO2 content. We observe that the breakdown limit strongly depends on the gas and that a higher
amount of quencher in the mixture does not necessarily correlate with higher stability. In
addition, we observe discharge probability scaling with the wire pitch. This suggests that a
Micromegas mesh cell can be treated as an independent amplification unit, similar to a hole in a
GEM foil. The outcome of these studies provides valuable input for further optimization of MPGD
detectors, multi-layer stacks in particular.