2022
DOI: 10.3389/fgene.2022.890641
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Systematic Investigation of Immune-Related lncRNA Landscape Reveals a Potential Long Non-Coding RNA Signature for Predicting Prognosis in Renal Cell Carcinoma

Abstract: Background: Renal cell carcinoma (RCC) is the predominant type of malignant tumor in kidney cancer. Finding effective biomarkers, particularly those based on the tumor immune microenvironments (TIME), is critical for the prognosis and diagnosis of RCC. Increasing evidence has revealed that long non-coding RNAs (lncRNAs) play a crucial role in cancer immunity. However, the comprehensive landscape of immune infiltration-associated lncRNAs and their potential roles in the prognosis and diagnosis of RCC remain lar… Show more

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“…Despite a number of immune-related lncRNA signatures, to our knowledge, the present study was the first to identify a TIL-related lncRNA signature to predict the prognosis of ccRCC patients. Compared with previous studies, which only established signatures ( 26 , 46 ), our novel signature was used to establish a nomogram combined with clinical indicators to accurately predict survival. As for the study with nomogram construction ( 24 ), the potential mechanism of our signature was verified with experiments.…”
Section: Discussionmentioning
confidence: 99%
“…Despite a number of immune-related lncRNA signatures, to our knowledge, the present study was the first to identify a TIL-related lncRNA signature to predict the prognosis of ccRCC patients. Compared with previous studies, which only established signatures ( 26 , 46 ), our novel signature was used to establish a nomogram combined with clinical indicators to accurately predict survival. As for the study with nomogram construction ( 24 ), the potential mechanism of our signature was verified with experiments.…”
Section: Discussionmentioning
confidence: 99%