2009
DOI: 10.1007/s10404-009-0489-3
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Systematic linearisation of a microfluidic gradient network with unequal solution inlet viscosities demonstrated using glycerol

Abstract: This paper presents a mathematical and experimental study of the effect of inlet concentration (and therefore viscosity) of glycerol solutions on the performance of a microfluidic network. This was achieved with analytical modelling, implemented in MATLAB, and optical measurement of the entire concentration distribution of the network. A mathematical proposal to improve the linearity of the outlet profile is also implemented and successfully verified experimentally. The concentration gradients of a two inlet-s… Show more

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Cited by 10 publications
(5 citation statements)
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“…The resulting profiles of both concentrations and flow rates will differ from the case with homogeneous fluids: deviated concentrations and unequal outlet flow rates. 255 Often, this fact enables us to measure viscosity of an unknown sample using microfluidic devices. [256][257][258][259][260] Time-variant flow.…”
Section: Advanced Aspects and Outlookmentioning
confidence: 99%
“…The resulting profiles of both concentrations and flow rates will differ from the case with homogeneous fluids: deviated concentrations and unequal outlet flow rates. 255 Often, this fact enables us to measure viscosity of an unknown sample using microfluidic devices. [256][257][258][259][260] Time-variant flow.…”
Section: Advanced Aspects and Outlookmentioning
confidence: 99%
“…As indicated by numerical simulations, a critical channel length exists corresponding to each ow rate in order to guarantee enough diffusive time for complete mixing. 55,56 The channel length should be larger than the critical value for the designed ow rate or the ow rate should be kept within the specic range for the dened channel Fig. 1 The equivalent electronic circuit model of the tree-shape network shown in Table 1.…”
Section: Concentration Gradient Generation Methods Based On Microfluimentioning
confidence: 99%
“…For high-throughput applications, recently several dilution/mixing techniques and devices have been reported for automatic solution preparation with CMF-based LoC's [Lee et al 2009;Yusuf et al 2009]. Similarly, a number of algorithms have appeared in the literature for diluting fluids on a DMF platform [Ren et al 2003], GAG [Griffith et al 2006], twoWayMix [Thies et al 2008], DMRW [Roy et al 2010], IDMA [Roy et al 2011a], MD [Bhattacharjee et al 2012], REMIA [Huang et al 2012], GORMA [Chiang et al 2013], WARA , NFSP [Dinh et al 2014], and for mixing a number of reagents such as MinMix [Thies et al 2008], RMA [Roy et al 2011b], RSM [Hsieh et al 2012], MTCS [Kumar et al 2013], CoDOS ].…”
Section: Introductionmentioning
confidence: 99%