In the past decade, advancements in endovascular techniques have revolutionized the management of abdominal aortic aneurysms (AAA). However, along with these advancements, clinicians face a rising incidence of complications, notably infections of vascular prostheses. Mycotic aortic aneurysm (MAA) represents a rare yet potentially life-threatening complication characterized by infection-induced damage to the native aorta. While microbiology predominantly implicates skin commensals, various pathogens, including Clostridium perfringens (CP), have been reported. Markedly, no cases of MAA caused by CP involving prosthetic material have been documented. Here, we present a unique case of a 76-year-old patient with MAA and abdominal prosthetic aortitis caused by Clostridium perfringens, accompanied by a comprehensive literature review.