Systematic Literature Review of Role of Noroviruses in Sporadic Gastroenteritis

Patel, Manish; Widdowson, Marc‐Alain; Glass, Roger I.; Akazawa, Kenichiro; Vinjé, Jan; Parashar, Umesh D.

doi:10.3201/eid1408.071114

Cited by 875 publications

(760 citation statements)

References 39 publications

Supporting

Mentioning

717

Contrasting

Unclassified

Order By: Relevance

“…In the population of children studied, norovirus infections were significantly less severe than rotavirus infections. The literature concerning symptom severity in norovirus and rotavirus gastroenteritis is heterogeneous [42]. A number of previous studies found lower levels of disease severity in norovirus than in rotavirus gastroenteritis, and most of these were carried out in developed countries [7,[43][44][45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and clinical features of gastroenteritis in hospitalised children: prospective survey during a 2-year period in a Parisian hospital, France

Lorrot

Bon

Hajje

et al. 2010

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

International audienceRotavirus is recognised as the most important agent of severe acute gastroenteritis (AGE) in young children. In a 2-year prospective survey, we investigated the epidemiology and clinical features of the viral and bacterial pathogens in children hospitalised for AGE. The study was performed in a Parisian teaching hospital from November 2001 to May 2004. Clinical data were prospectively collected to assess the gastroenteritis severity (20-point Vesikari severity score, the need for intravenous rehydration, duration of hospitalisation). Stools were systematically tested for group A rotavirus, norovirus, astrovirus and adenovirus 40/41, sapovirus and Aichi virus and enteropathogenic bacteria. A total of 457 children (mean age 15.9 months) were enrolled. Viruses were detected in 305 cases (66.7%) and bacteria in 31 cases (6.8%). Rotaviruses were the most frequent pathogen (48.8%), followed by noroviruses (8.3%) and adenoviruses, astroviruses, Aichi viruses and sapoviruses in 3.5%, 1.5%, 0.9% and 0.4%, respectively. Cases of rotavirus gastroenteritis were significantly more severe than those of norovirus with respect to the Vesikari score, duration of hospitalisation and the need for intravenous rehydration. Rotaviruses were the most frequent and most severe cause in children hospitalised for AGE, and noroviruses also account for a large number of cases in this population

show abstract

Section: Discussionmentioning

confidence: 99%

Epidemiology and clinical features of gastroenteritis in hospitalised children: prospective survey during a 2-year period in a Parisian hospital, France

Lorrot

Bon

Hajje

et al. 2010

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

show abstract

“…Norovirus is the most common cause of infectious intestinal disease (IID) in the community in high-income countries (1)(2)(3)(4), and a substantial prevalence of norovirus infection has been reported among IID cases seeking medical care (5). Existing estimates of norovirus-associated IID incidence in the community and among individuals presenting to their general practitioner in England are based on electron microscopy, which has poor diagnostic sensitivity for identifying norovirus-associated IID (6)(7)(8); it is very likely that these estimates underrepresent the burden of norovirus disease.…”

mentioning

confidence: 99%

Prevalence and characteristics of asymptomatic norovirus infection in the community in England

et al. 2010

View full text Add to dashboard Cite

Existing estimates of the incidence of infectious intestinal disease (IID) caused by norovirus are based on electron microscopy or reverse transcription-polymerase chain reaction (RT-PCR). Neither method accurately represents norovirus disease burden: Electron microscopy has poor diagnostic sensitivity, and RT-PCR has poor diagnostic specificity. In this study, viral load measurements were used to identify cases of norovirus-associated IID and to produce new incidence estimates for England. IID cases were ascertained in the Study of Infectious Intestinal Disease in England (1993England ( -1996, and stool specimens were tested by semiquantitative real-time RT-PCR for norovirus. The age-adjusted community incidence of norovirus-associated IID was 4.5/100 person-years (95% credibility interval: 3.8, 5.2), equating to 2 million episodes/year. Among children aged less than 5 years, the community incidence was 21.4/100 person-years (95% credibility interval: 15.9, 27.7), and the incidence of consultations to general practitioners for norovirus-associated IID was 3.2/100 person-years (95% credibility interval: 2.6, 3.8), with 100,000 children visiting their general practitioner for norovirus-associated IID each year. Norovirus is the most common cause of IID in the community in England and is responsible for a similar number of pediatric primary care consultations as rotavirus.England; gastroenteritis; incidence; Monte Carlo method; Norovirus; primary health care; reverse transcriptase polymerase chain reaction Abbreviations: IID, infectious intestinal disease; ROC, receiver operating characteristic; RT-PCR, reverse transcription-polymerase chain reaction.

show abstract

“…Rotavirus A (RVA), norovirus (NoV) and human astrovirus (HAstV) have been described as the most important agents responsible for sporadic cases and outbreaks of acute gastroenteritis (AGE) worldwide (Patel et al 2008). Previous reports have demonstrated that RVA and NoV are common causes of nosocomial diarrhoea in paediatric populations admitted to hospitals (Tran et al 2010).…”

mentioning

confidence: 99%

Genotyping of gastroenteric viruses in hospitalised children: first report of norovirus GII.21 in Brazil

Ferreira

Garcia

Xavier

et al. 2012

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

This retrospective study (April-September 2003) was designed to investigate the roles of the main viruses responsible for cases of acute infantile gastroenteritis in hospitalised children up to two years of age. The viruses were identified in 64.7% (88/136) of the cases and the detection rates of rotavirus A (RVA), norovirus (NoV) and astrovirus were 41.9% (57/136), 30.3% (24/79) and 12.7% (7/55), respectively. RVA and NoV were detected in 20 of the 24 reported nosocomial infection cases. This study identified the first circulation of the genotype NoV GII.21 in Brazil and highlights the need to establish differential diagnoses through active laboratorial surveillance

show abstract

Systematic Literature Review of Role of Noroviruses in Sporadic Gastroenteritis

Cited by 875 publications

References 39 publications

Epidemiology and clinical features of gastroenteritis in hospitalised children: prospective survey during a 2-year period in a Parisian hospital, France

Epidemiology and clinical features of gastroenteritis in hospitalised children: prospective survey during a 2-year period in a Parisian hospital, France

Prevalence and characteristics of asymptomatic norovirus infection in the community in England

Genotyping of gastroenteric viruses in hospitalised children: first report of norovirus GII.21 in Brazil

Contact Info

Product

Resources

About