Systematic Pan-Cancer Analysis of KIF23 and a Prediction Model Based on KIF23 in Clear Cell Renal Cell Carcinoma (ccRCC)

Bai, Xiaojie; Cao, Yuanfei; Yan, Xin; Tuoheti, Kurerban; Du, Guo-Wei; Zhao, Chen; Wu, Hua-Hui; Guo, Linfa; Liu, Tongzu

doi:10.2147/pgpm.s337695

Cited by 6 publications

(7 citation statements)

References 37 publications

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“…However, there seldom exists a perfect indicating effect for the genes investigated in the current study. The pan-cancer analysis of KIF23 showed that it had a close correlation with the clinical stage and it was higher along with the higher clinical stage, but the research did not further explore the PFI and other survival index [ 9 ]. At the same time, in the research conducted by the Yun Chen, TGFBI was also elevated in various kinds of cancers (cholangiocarcinoma, colon adenocarcinoma (COAD), esophageal carcinoma (ESCA), GBM, head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), liver hepatocellular carcinoma (LIHC), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), and thyroid carcinoma), and it also showed a great value in the survival aspects.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Pan‐Cancer Analysis of Prognostic and Immune Infiltrates for the TMEM65, Especially for the Breast Cancer

Song

Wang

Feng

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Introduction. Transmembrane protein 65 (TMEM65) is an inner mitochondrial membrane protein, which played important role in mediating autophagy, smooth muscle contraction, protein glycosylation, and immune response. In recent years, the interest had risen for exploring the function of the TMEM genes in the cancer fields. As a consequence, in our pan-cancer research of the TMEM65, we explored the function of the gene in kinds of database and tried to apply the finding in the clinical practice. Methods. In this research, we provide a comprehensive investigation of TMEM65 expression in a pan-cancer manner containing 33 cancer types. We evaluated the association of TMEM65 with the prognosis, immune infiltration, drug sensitivity analysis, GSVA enrichment analysis, TMB, MSI, NEO, and hotspot mechanisms. Results. TMEM65 was abnormally expressed in 24 types of cancers and showed correlation with the OS for 6 cancers and PFI for 9 cancers and kpI for 3 types. Moreover, the TME score, CD8 T effector, and immune checkpoint scoring systems showed a close correlation with the TMEM65. Moreover, TMEM65 was strongly correlated with some of the most common tumor-related genes and certain pathways (TGF beta signaling, TNFA signaling, hypoxia, pyroptosis, DNA repairing, autophagy, ferroptosis, and other related genes). Additionally, the TMEM65 showed correlations with the tumor mutational burden (TMB), microsatellite instability (MSI), NEO, and drug sensitivity. Finally, we confirmed several pathways by the GSEA and GSVA for the TMEM65 at the breast cancer aspects. Nomogram prediction model was also established for the breast tumors based on the TMEM65 level and other variables. Conclusion. Above all, the TMEM65 played important roles in predicting the prognosis of the cancers and correlated with the tumor immunity in the pan-cancer analysis.

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Section: Discussionmentioning

confidence: 99%

[Retracted] Pan‐Cancer Analysis of Prognostic and Immune Infiltrates for the TMEM65, Especially for the Breast Cancer

Song

Wang

Feng

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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“…It actively participates in the development of the cell membrane during the cell division process. Aberrant expression or activity may result in excessive cell proliferation and is associated with the invasion and migration of tumor cells [29]. KIF23 dysfunction leads to mitotic arrest and the appearance of binucleated or multinucleated cells, which in turn leads to tumorigenesis [30].…”

Section: The Protein Expression Of Ccna2 and Kif23mentioning

confidence: 99%

CCNA2 and KIF23 are molecular targets for the prognosis of adenoid cystic carcinoma

Di,

Zhang,

Zhang

et al. 2024

Aging

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Objective: Adenoid cystic carcinoma (ACC) is a tumor type derived from glands. However, relationship between CCNA2 and KIF23, and adenoid cystic carcinoma remains unclear. Methods: GSE36820 and GSE88804 profiles for ACC were obtained from the Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) were identified, and Weighted Gene Co-expression Network Analysis (WGCNA) was conducted. Subsequently, the construction and analysis of protein-protein interaction (PPI) network, functional enrichment analysis, and Gene Set Enrichment Analysis (GSEA) were performed. A gene expression heat map was generated to visually depict the expression difference of core genes between adenoid cystic carcinoma and normal samples. TargetScan was employed to identify miRNAs that regulated central DEGs. Western blotting (WB) was conducted for cell verification. Results: A total of 885 DEGs were identified. GO and KEGG analyses revealed their main enrichment in responses to chemical stimuli, cell proliferation, tissue development, and regulation of cell proliferation. The GO and KEGG results indicated significant enrichment in aldosterone-regulated sodium reabsorption, the cell cycle, and the PPAR signaling pathway. Notably, core genes (CCNA2 and KIF23) were found to be highly expressed in Adenoid Cystic Carcinoma samples and expressed at low levels in normal samples. WB validated the overexpression of CCNA2 and KIF23 in the Adenoid Cystic Carcinoma group, confirming the protein-level changes associated with cell cycle, metastasis, apoptosis, and inflammatory factors in Adenoid Cystic Carcinoma groups with gene overexpression and knockout. Conclusions: CCNA2 and KIF23 exhibit high expression levels in ACC, suggesting their potential role as molecular targets for this malignancy.

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“…Five FI-DEGs (CCR4, CMTM3, IFITM1, MX2, and NR3C2) could be used as biomarkers to predict the outcome and diagnosis of KIRC in patients [105]. Evidence suggests that KIF23 may have an important role in the onset and progression of many cancers [106]. It can be an effective predictive biomarker in ccRCC, and the nomogram based on KIF23 may help with improved treatment recommendations for ccRCC patients [106].…”

Section: Ferroptosis and Kidney Diseasesmentioning

confidence: 99%

“…Evidence suggests that KIF23 may have an important role in the onset and progression of many cancers [106]. It can be an effective predictive biomarker in ccRCC, and the nomogram based on KIF23 may help with improved treatment recommendations for ccRCC patients [106]. Other studies reported that FDFT1 and acyl-CoA thioesterases 8 and 11 can be used as new biomarkers for ccRCC [107, 108].…”

Section: Ferroptosis and Kidney Diseasesmentioning

confidence: 99%

Novel Insight into Ferroptosis in Kidney Diseases

Liu¹,

Liu²,

Zhou³

et al. 2023

Am J Nephrol

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Background: Various kidney diseases such as acute kidney injury, chronic kidney disease, polycystic kidney disease, renal cancer, and kidney stones, are an important part of the global burden, bringing a huge economic burden to people around the world. Ferroptosis is a type of nonapoptotic iron-dependent cell death caused by the excess of iron-dependent lipid peroxides and accompanied by abnormal iron metabolism and oxidative stress. Over the past few decades, several studies have shown that ferroptosis is associated with many types of kidney diseases. Studying the mechanism of ferroptosis and related agonists and inhibitors may provide new ideas and directions for the treatment of various kidney diseases. Summary: In this review, we discuss the differences between ferroptosis and other types of cell death such as apoptosis, necroptosis, pyroptosis, cuprotosis, pathophysiological features of the kidney, and ferroptosis-induced kidney injury. We also provide an overview of the molecular mechanisms involved in ferroptosis and events that lead to ferroptosis. Furthermore, we summarize the possible clinical applications of this mechanism among various kidney diseases. Key Message: The current research suggests that future therapeutic efforts to treat kidney ailments would benefit from a focus on ferroptosis.

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Systematic Pan-Cancer Analysis of KIF23 and a Prediction Model Based on KIF23 in Clear Cell Renal Cell Carcinoma (ccRCC)

Cited by 6 publications

References 37 publications

[Retracted] Pan‐Cancer Analysis of Prognostic and Immune Infiltrates for the TMEM65, Especially for the Breast Cancer

[Retracted] Pan‐Cancer Analysis of Prognostic and Immune Infiltrates for the TMEM65, Especially for the Breast Cancer

CCNA2 and KIF23 are molecular targets for the prognosis of adenoid cystic carcinoma

Novel Insight into Ferroptosis in Kidney Diseases

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