“…Several of the activities of individual polyadenylation complex subunits are affected by phosphorylation, methylation, calmodulin, disulfide remodeling, and ubiquitin (Jacob and Rose, 1984;Thuresson et al, 1994;Colgan et al, 1996;Mizrahi and Moore, 2000;Mouland et al, 2002;Delaney et al, 2006;Ryan, 2007;Addepalli and Hunt, 2008;Ryan and Bauer, 2008;Addepalli et al, 2010;Martin et al, 2010). In addition, alterations in the activities of individual poly(A) complex subunits are often accompanied by large-scale shifts in poly(A) site choice (Jenal et al, 2012;Martin et al, 2012;Thomas et al, 2012;Duc et al, 2013;Li et al, 2015). Hypoxia is associated with transient activation of MPKs and spikes in cytosolic calcium as well as dynamics in reactive oxygen species, along with a reduction in ATP availability and a shift to anaerobic metabolism that can alter cytosolic pH (Chang et al, 2012).…”