Systematic psychiatric assessment of patients with sickle cell disease

Zahrani, Omar S. Al; Mukhtar, Osama; Subaie, Menahi Al; Howiti, Wazenah E. Al

doi:10.15537/smj.2019.1.22919

Cited by 6 publications

(10 citation statements)

References 19 publications

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“…According to the depression categories and based on the cutoff, the depression rate was 45.4%, which was represented by the (moderate-moderately severe-severe) depression categories; however, the nondepressed is a little higher (54.1%) than depressed patients, which is represented by (nondepressed-mild) depression categories. These findings were compatible with a study conducted in Tabuk that reported a depression rate was 36% and nondepressed SCD patients were 64% [ 11 ]. Furthermore, we found that the rate of anxiety in our study was 22.7%, which was less than that reported by Tabuk and Levenson et al [ 11 , 20 ].…”

Section: Discussionsupporting

confidence: 92%

“…These findings were compatible with a study conducted in Tabuk that reported a depression rate was 36% and nondepressed SCD patients were 64% [ 11 ]. Furthermore, we found that the rate of anxiety in our study was 22.7%, which was less than that reported by Tabuk and Levenson et al [ 11 , 20 ].…”

Section: Discussionsupporting

confidence: 92%

“…Single and unemployed patients were more depressed than others. In contrast, the anxiety levels of the patients with high education levels were higher than those with low educational levels [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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The Prevalence of Depression and Anxiety Among Sickle Cell Disease Patients in King Abdulaziz University Hospital

Al-Marzouki¹,

Alrefaie²,

Aljohani³

et al. 2021

Cureus

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Background Sickle cell disease (SCD) is a recessive hereditary condition. The physical changes caused by SCD affect the quality of life (QoL) by negatively impacting psychological aspects. Objective This study aimed to assess the prevalence of depression and anxiety in SCD patients based on different sociodemographic characteristics in Jeddah, Saudi Arabia. Method A cross-sectional study was conducted at King Abdulaziz University Hospital (KAUH) in Jeddah from 13 July to 30 August 2021. The included patients were 18 years of age and above and affected with sickle cell disease. Medical staff interviewed the patients and filled the Patient Health Questionnaire (PHQ)-9 and General Anxiety Disorder (GAD)-7. Result One hundred nineteen (119) patients were included in this study. The median age of participants was 32 and mostly male (n=72, 60.5%). The rate of depression was 45.4%. On the other hand, the rate of anxiety was 22.7%. The median of the PHQ-9 score was 8±8 while the median of the GAD-7 score was 5±8. Moreover, the study showed that anxiety and depression in relation to sociodemographics were higher in the patient age groups of 30-34 years old, male, single, unemployed, and with higher education. There was a significant association between depression rate and the two variables: patient employment status (49.3%; p=0.047) and a family history of SCD (51%). Conclusion Depression in patients with sickle cell disease is prevalent and correlated to demographic and social factors.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

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The Prevalence of Depression and Anxiety Among Sickle Cell Disease Patients in King Abdulaziz University Hospital

Al-Marzouki¹,

Alrefaie²,

Aljohani³

et al. 2021

Cureus

View full text Add to dashboard Cite

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“…Therefore, it seems that the presence of chronic diseases does not explain the higher odds of depression observed in this study compared to those with lower percentages of chronic diseases. In addition, the rate of depression in MG patients in this study is comparable to the rate of depression among Saudi patients with sickle cell disease and gastrointestinal disorders [24, 25], but significantly less than that among patients with hematological malignancies and multiple sclerosis [26, 27].…”

Section: Discussionsupporting

confidence: 54%

Prevalence and Associated Factors of Depressive Symptoms in Patients with Myasthenia Gravis: A Cross-Sectional Study of Two Tertiary Hospitals in Riyadh, Saudi Arabia

Alanazy

2019

Behavioural Neurology

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Objectives. This study is aimed at elucidating the prevalence of depression in patients with myasthenia gravis (MG) and examining the risk factors associated with depression. Methods. We evaluated adult patients with MG who were recruited from two tertiary hospitals in the central region (Riyadh) of Saudi Arabia. Data were collected with a two-part standardized questionnaire: the first part included data on sociodemographic and clinical features of MG including disease type and duration, therapies, prednisolone dose, time of the last relapse, previous critical care unit admissions, MG status (controlled, partially controlled, or uncontrolled), and comorbid diseases; the second part included items from the previously validated Arabic version of the Patient Health Questionnaire-9 (PHQ-9). Results. In total, 104/150 (69.3%) patients participated (72 females) with a mean age of 38.0±16.0 years. The mean PHQ-9 score was 7.02±6.1. Among all the participants, 27 (26.0%) patients had depression (PHQ‐9≥10). Multiple logistic regression analysis revealed that uncontrolled MG status (OR=12.31, 95%CI=1.13‐133.8, P=0.04) was the only factor independently associated with depression. Collectively, the prevalence of depression among patients of the primary care clinics (PCC) as reported by 5 previous studies across multiple regions of the country was 15.8%. The odds of depression among MG patients were twofold higher than those among PCC patients (OR=2.05, 95%CI=1.30‐3.22, P=0.002). Conclusions. Approximately a quarter of MG patients have depression. Achieving a minimal manifestation or better MG status may decrease the depression rate in these patients.

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“…We cannot deduce from these results the percentage of patients suffering from psychological disorders. In other studies, the proportion of SCD patients reporting psychological disturbances was very variable: 18 to 62% for depressive symptoms and 7 to 67% for anxiety symptoms [26,[49][50][51][52].…”

Section: Medication and Psychoactive Substances Usementioning

confidence: 78%

Descriptive analysis of sickle cell patients living in France: The PHEDRE cross-sectional study

et al. 2021

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Background Sickle cell disease (SCD) induces chronic haemolytic anaemia and intermittent vaso-occlusion that results in tissue ischaemia causing acute, severe pain episodes that can lead to frequent hospitalizations. These consequences can have repercussions on family, social, school and/or professional life. Here, we present some of the results of the PHEDRE study (Pharmacodépendance Et DREpanocytose—drug dependence and sickle-cell disease), which is the largest study of patients with SCD in France. This paper intends to describe characteristics of the French SCD population. We also aimed to assess the impact of the disease on the lives of patients using objective and subjective variables. Methods The PHEDRE study was a national multicentric observational study. Adults, adolescents and children with a confirmed SCD diagnosis were included in the study by their referring doctor. Then, they were interviewed by phone about their socioeconomic status, about the impact of the disease on their lives and about their analgesic and psychoactive drug use. Results The study population consisted of 872 patients (28% were minors). Seventy-two percent of adults were active, and all minors were in school. Many patients presented criteria of severe SCD. Seventy-five percent were homozygous SS, 15% were double heterozygotes SC and 8% were heterozygotes Sβthal, 87% received specific treatment, 58% were hospitalized at least once for vaso-occlusive crisis in the past 12 months, and the number of analgesic drugs taken averaged 3.8. Seventy-five percent of patients reported academic or professional consequences related to their SCD, and 52% reported social consequences. Conclusions The impact of SCD on patients’ lives can be significant, nevertheless their social integration seems to be maintained. We highlighted respect of recommendations regarding analgesic treatments and only a few patients used tobacco, alcohol or cannabis. Trial registration Clinical Trials, NCT02580565; https://clinicaltrials.gov/ Registered 16 October 2015.

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Systematic psychiatric assessment of patients with sickle cell disease

Cited by 6 publications

References 19 publications

The Prevalence of Depression and Anxiety Among Sickle Cell Disease Patients in King Abdulaziz University Hospital

The Prevalence of Depression and Anxiety Among Sickle Cell Disease Patients in King Abdulaziz University Hospital

Prevalence and Associated Factors of Depressive Symptoms in Patients with Myasthenia Gravis: A Cross-Sectional Study of Two Tertiary Hospitals in Riyadh, Saudi Arabia

Descriptive analysis of sickle cell patients living in France: The PHEDRE cross-sectional study

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