Systematic re‑analysis strategy of serum indices identifies alkaline phosphatase as a potential predictive factor for cervical cancer

Abstract

The aim of the present study was to identify predictive factors for cervical cancer (CC) progression using a multistage approach. The present study obtained data from 390 healthy women and 259 patients with cervical cancer between June 2012 and June 2017, and used a multiple stage re-analysis strategy for clinical detection of CC. A total of seven types of serum indices were used in the present study, including sugar chain antigen 125 (CA-125), sugar chain antigen 199 (CA-199), α fetoprotein (AFP), carcino- embryonic antigen, alkaline phosphatase (ALP), cholesterol and triglyceride (TG). The expression levels of CA-125, CA-199, AFP, ALP, cholesterol and TG were significantly different between healthy women and patients with cervical squamous cell carcinoma (SCC). Furthermore, ALP, cholesterol and TG expression levels were significantly different in healthy women compared with patients with cervical adenocarcinoma (AC). Further comparisons based on age and pathological staging demonstrated that the variability in the ALP level was not significant between the <40 years old age group and the 40–50 years old age group within healthy individuals (P>0.05); however, was significant in patients with SCC (P<0.05). Staging analysis identified significant differences in ALP between healthy women and patients with SCC (Stage I–IV), and significant differences between healthy women and patients with Stage I AC. The results of the present study indicated that the expression of ALP was significantly increased in patients with CC compared with healthy women. Therefore, ALP may be a potential predictive factor for the development of CC.

<p>The Prognostic Significance Of Pretreatment Albumin/alkaline Phosphatase Ratio In Patients With Stage IB-IIA Cervical Cancer</p>

“…40 Moreover, a recent published article found that high levels of ALP could influence tumorigenesis and predict outcomes in cervical cancer patients. 41 In our present study, the AUC of AAPR was similar to that of ALB and ALP. However, AAPR has several advantages in cervical cancer patients compared with the other two indices.…”

Hematological Indicator-Based Machine Learning Models for Preoperative Prediction of Lymph Node Metastasis in Cervical Cancer

“…However, the speci c mechanism of the above-mentioned indicators as predictors of LNM in CC patients is unclear, and further studies are warranted. Furthermore, it has been suggested that some hematological parameters that were not used in this study, such as sugar chain antigen 125 (CA125), sugar chain antigen 199 (CA19-9), α fetoprotein (AFP), and alkaline phosphatase (ALP), may also be associated with LNM in CC patients, which may also provide a feasible direction for future research [42] .…”

The Adler grade by Doppler ultrasound is associated with clinical pathology of cervical cancer: Implication for clinical management

“…Several studies have shown that cervical cancer is also closely related to the marker CA125 and CA199. It has been reported [ 42 – 44 ] that the carbohydrate antigens CA125 and CA199 are expressed at high levels in a variety of malignancies. In this study, the levels of CA125 and CA199 in patients with adenocarcinoma were significantly higher than those in patients with squamous cell carcinoma.…”